COL4A Inhibitors
The class of chemicals known as COL4A inhibitors comprises a diverse array of compounds that intricately modulate COL4A expression through various cellular pathways. These inhibitors exploit signaling cascades and cellular processes to indirectly influence the levels of COL4A. One such example is dimethyl sulfoxide (DMSO), which, acting as a solvent, possesses demethylating properties capable of altering the epigenetic landscape. This alteration impacts COL4A expression by modifying the chromatin structure and accessibility of the COL4A gene for transcriptional machinery. The ability of DMSO to influence COL4A through epigenetic modifications highlights the complex regulatory mechanisms involved in gene expression.
In addition to DMSO, compounds like Y-27632 and SB431542 target specific signaling pathways to modulate COL4A expression. Y-27632 inhibits Rho-associated protein kinases (ROCK), affecting cytoskeletal dynamics and indirectly influencing COL4A levels. The disruption of the Rho/ROCK pathway showcases the intricate interplay between cytoskeletal processes and the regulation of COL4A. SB431542, on the other hand, targets the transforming growth factor-beta (TGF-β) signaling pathway. By inhibiting this pathway, SB431542 reveals a cascade of events that indirectly modulate COL4A levels, further emphasizing the interconnected nature of cellular signaling in the regulation of gene expression. These inhibitors collectively provide valuable insights into the complex regulatory network governing COL4A expression. The multifaceted mechanisms employed by DMSO, Y-27632, and SB431542 underscore the intricate interplay between various cellular pathways and their impact on COL4A levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO is a solvent that has been shown to modulate cellular processes indirectly. It can influence COL4A expression by altering the epigenetic landscape through its demethylating properties. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinases (ROCK), affecting the Rho/ROCK pathway. By inhibiting ROCK, Y-27632 indirectly influences COL4A expression through the regulation of actin dynamics and cytoskeletal organization. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a potent inhibitor of the TGF-β type I receptor, blocking the TGF-β signaling pathway. As COL4A is associated with TGF-β signaling, SB431542 indirectly modulates COL4A expression by disrupting this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor, impacting the PI3K/Akt pathway. This indirectly influences COL4A expression by disrupting downstream signaling events mediated by Akt. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective JNK inhibitor, affecting the JNK signaling pathway. By modulating JNK activity, SP600125 indirectly influences COL4A expression, as JNK is involved in the regulation of various cellular processes, including gene expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific PI3K inhibitor that disrupts the PI3K/Akt pathway. This impacts COL4A expression indirectly by interfering with the downstream signaling events mediated by Akt. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective MEK inhibitor, affecting the MAPK/ERK pathway. Its indirect influence on COL4A involves the modulation of the MAPK/ERK pathway, which plays a role in regulating gene expression, including that of COL4A. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation, influencing the NF-κB signaling pathway. By disrupting NF-κB signaling, BAY 11-7082 indirectly modulates COL4A expression, as NF-κB is involved in the regulation of various genes, including COL4A. | ||||||
SP2509 | 1423715-09-6 | sc-492604 | 5 mg | $284.00 | ||
SP2509 is a small-molecule inhibitor of LSD1, impacting histone demethylation. Its indirect effect on COL4A involves the alteration of the epigenetic landscape, influencing the transcriptional regulation of COL4A through changes in histone methylation patterns. | ||||||
LY2090314 | 603288-22-8 | sc-507359 | 5 mg | $175.00 | ||
LY2090314 is a potent inhibitor of glycogen synthase kinase 3 (GSK-3), influencing the Wnt signaling pathway. By modulating Wnt signaling, LY2090314 indirectly impacts COL4A expression, as Wnt signaling is implicated in the regulation of extracellular matrix components. | ||||||