COL2A1 Activators
COL2A1 Activators constitute a specific category of chemical compounds known for their capability to modulate the activity of collagen type II alpha 1 chain (COL2A1). This chemical class operates by interacting with and enhancing the signaling pathways associated with COL2A1, a key component of collagen type II, a structural protein found primarily in cartilage and other connective tissues. COL2A1 is integral to the maintenance of tissue integrity, skeletal development, and cartilage resilience.
COL2A1 Activators exert their influence through specific molecular interactions that may amplify the downstream effects of COL2A1-mediated signaling, contributing to the fine-tuning of extracellular matrix composition, tissue architecture, and cellular interactions within connective tissues. The intricate mechanisms through which COL2A1 Activators impact COL2A1-related pathways remain a focus of ongoing scientific investigation, providing insights into the complex interplay between tissue formation, maintenance, and functional adaptability. The specific ways in which this chemical class engages with COL2A1 underscore its significance in unraveling the intricacies of connective tissue biology and enhancing our understanding across various scientific domains.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is a potent and selective inhibitor of the TGF-β type I receptor, ALK5. By blocking TGF-β signaling, SB431542 influences chondrogenesis, the process by which chondrocytes differentiate and produce collagen, including COL2A1. Inhibition of TGF-β signaling may indirectly impact COL2A1 activation by modulating the pathways that govern chondrocyte development and collagen synthesis. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
A83-01 is a potent inhibitor of TGF-β type I receptors, including ALK5. By suppressing TGF-β signaling, A83-01 can impact chondrogenesis and collagen synthesis, including COL2A1. The inhibition of TGF-β pathways by A83-01 may indirectly influence COL2A1 activation by modulating the molecular processes governing chondrocyte differentiation and collagen production. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences cartilage development and can induce COL2A1 expression during chondrogenesis. | ||||||
LY2109761 | 700874-71-1 | sc-396262 sc-396262A | 1 mg 5 mg | $89.00 $275.00 | 9 | |
LY2109761 is a TGF-β receptor type I and II dual inhibitor. By blocking TGF-β signaling, LY2109761 can impact chondrogenesis and collagen synthesis, including COL2A1. Inhibition of TGF-β pathways by LY2109761 may indirectly influence COL2A1 activation, affecting the molecular processes governing chondrocyte differentiation and collagen production in the context of cartilage development. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $213.00 $318.00 $632.00 $1047.00 | 2 | |
DMH1 is a selective inhibitor of BMP signaling by targeting the BMP type I receptors, including ALK2. BMP signaling is crucial for chondrogenesis and cartilage development, influencing collagen synthesis, including COL2A1. DMH1 can indirectly modulate COL2A1 activation by disrupting BMP signaling pathways involved in chondrocyte differentiation and collagen production, key processes for maintaining cartilage integrity. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $77.00 $153.00 $219.00 $663.00 $1248.00 $4382.00 $7850.00 | 8 | |
ALK5 Inhibitor II is an inhibitor of TGF-β type I receptors, including ALK5. By blocking TGF-β signaling, RepSox influences chondrogenesis, the process by which chondrocytes differentiate and produce collagen, including COL2A1. Inhibition of TGF-β pathways by RepSox may indirectly impact COL2A1 activation by modulating the pathways that govern chondrocyte development and collagen synthesis. | ||||||
DMH 4 | 515880-75-8 | sc-497273 | 10 mg | $380.00 | ||
DMH4 is a selective inhibitor of BMP type I receptors, including ALK2. BMP signaling is integral to chondrogenesis and cartilage development, affecting collagen synthesis, including COL2A1. DMH4 can indirectly modulate COL2A1 activation by disrupting BMP signaling pathways, influencing chondrocyte differentiation and the production of collagen, essential for maintaining the structural integrity of cartilage. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
LY2157299 is a TGF-β receptor type I inhibitor, targeting ALK5. By suppressing TGF-β signaling, Galunisertib can impact chondrogenesis and collagen synthesis, including COL2A1. The inhibition of TGF-β pathways by Galunisertib may indirectly influence COL2A1 activation by modulating the molecular processes governing chondrocyte differentiation and collagen production. | ||||||
ITD 1 | 1099644-42-4 | sc-507349 | 10 mg | $220.00 | ||
ITD-1 is a selective inhibitor of TGF-β receptor type I kinase, ALK5. By blocking TGF-β signaling, ITD-1 influences chondrogenesis and collagen synthesis, including COL2A1. Inhibition of TGF-β pathways by ITD-1 may indirectly impact COL2A1 activation by modulating the pathways that govern chondrocyte development and collagen synthesis. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $186.00 $751.00 | 28 | |
Dorsomorphin is an inhibitor of BMP type I receptors, including ALK2. BMP signaling is integral to chondrogenesis and cartilage development, influencing collagen synthesis, including COL2A1. Dorsomorphin can indirectly modulate COL2A1 activation by disrupting BMP signaling pathways, influencing chondrocyte differentiation and the production of collagen, essential for maintaining the structural integrity of cartilage. | ||||||