COL2A1 Antibody (M2139): sc-52658

COL2A1 Antibody (M2139) is a mouse monoclonal IgG2b kappa light chain antibody that detects Collagen Type II protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-COL2A1 antibody (M2139) is available as a non-conjugated format. Collagen Type II is primarily located in cartilage, where it forms a significant part of the extracellular matrix, providing structural support and resilience to this tissue. This localization is crucial because cartilage serves as a cushion between bones in joints, facilitating smooth movement and absorbing shock during physical activity. The integrity of Collagen Type II is vital for maintaining cartilage health, and degradation is associated with various joint disorders, including osteoarthritis and rheumatoid arthritis. The extensive family of collagen proteins, including Collagen Type II, is characterized by a unique triple helix structure that allows for fibril formation, contributing to the tensile strength and stability of connective tissues. Understanding Collagen Type II′s role in cartilage highlights its importance in joint function and potential as a therapeutic target in degenerative diseases.

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COL2A1 Antibody (M2139) References:

1. Col2a1 lineage tracing reveals that the meniscus of the knee joint has a complex cellular origin.  |  Hyde, G., et al. 2008. J Anat. 213: 531-8. PMID: 19014360
2. Skeletal deterioration in COL2A1-related spondyloepiphyseal dysplasia occurs prior to osteoarthritis.  |  Rolvien, T., et al. 2020. Osteoarthritis Cartilage. 28: 334-343. PMID: 31958497
3. Novel variants in COL2A1 causing rare spondyloepiphyseal dysplasia congenita.  |  Zheng, WB., et al. 2020. Mol Genet Genomic Med. 8: e1139. PMID: 31972903
4. A novel deep intronic COL2A1 mutation in a family with early-onset high myopia/ocular-only Stickler syndrome.  |  Sun, W., et al. 2020. Ophthalmic Physiol Opt. 40: 281-288. PMID: 32196734
5. COL2A1 Is a Novel Biomarker of Melanoma Tumor Repopulating Cells.  |  Talluri, B., et al. 2020. Biomedicines. 8: PMID: 32962144
6. Exome sequencing revealed USP9X and COL2A1 mutations in a large family with multiple epiphyseal dysplasia.  |  Luo, ZJ., et al. 2022. Bone. 163: 116508. PMID: 35907616
7. The molecular complexity of COL2A1 splicing variants and their significance in phenotype severity.  |  Viakhireva, I., et al. 2024. Bone. 181: 117013. PMID: 38246255
8. Cell adhesion to collagenous matrices.  |  McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
9. Nasal tolerance to dominant and subdominant epitopes of collagen type II and protection against collagen-induced arthritis.  |  Staines, NA., et al. 1997. Biochem Soc Trans. 25: 661-4. PMID: 9191176
10. Versatile collagens in invertebrates.  |  Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
11. Collagen-induced arthritis, an animal model of autoimmunity.  |  Myers, LK., et al. 1997. Life Sci. 61: 1861-78. PMID: 9364191
12. The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease.  |  Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COL2A1 Antibody (M2139) has 172 citations in a variety of scientific publications.

Primary antibodies like Anti-COL2A1 Antibody (M2139) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COL2A1 Antibody (M2139) Specifications

Alternate Product Name: COL2A1

Product Clone Name: M2139

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: collagen II

Epitope Species: mouse

Product Reactivity/Detection: Collagen Type II

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: Arabadopsis

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 172 citations in various scientific publications

Available Conjugates/Forms for COL2A1 Antibody (M2139): N/A