ALK5 Inhibitor II is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). TGF β RI (ALK5) Inhibitor II affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16μM), minimally.
1. Gellibert, F. et al. 2004. J. Med. Chem. 47(18): 4494-4506. PMID: 15317461
2. Ichida, J.K., Blanchard, J., Lam, K., et al. Cell Stem Cell 5(5), 491-503 (2009).
A stock solution of can be made by dissolving in organic solvent purged with Inert Gas. Ethanol (2 mg/ml), DMSO, and DMF (20 mg/ml).
Soluble in DMSO (100 mM), methanol (5 mg/ml), and ethanol (50 mM).
Store at -20° C
501.91° C at 760 mmHg (Predicted)
1.30 g/cm3 (Predicted)
n20D 1.69 (Predicted)
Autophosphorylation of TGF-β RI kinase: IC50 = 4 nM (HepG2 cells); Cellular assay of TGF β RI kinase: IC50 = 18 nM (HepG2 cells); Binding of TGF-β RI kinase: IC50 = 23 nM (HepG2 cells); p38 MAPK: IC50 >16 µM; GSK3: IC50 >16 µM
pKa: 10.05 (Predicted), pKb: 2.82 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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ALK5 Inhibitor II Product Citations
See how others have used ALK5 Inhibitor II. Click on the entry to view the PubMed entry
Rated 5 out of
JajoskyJajosky, AN. et al. (PubMed 24855276) reported that RepSox (ALK5 Inhibitor II) slows decay of CD43+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. -SCBT Publication Review
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