Cntnap5c Inhibitors
Cntnap5c inhibitors are chemical compounds that specifically interact with and inhibit the activity of the Cntnap5c protein. Cntnap5c, or Contactin-associated protein-like 5C, is a member of the neurexin family, which plays a crucial role in the organization of neuronal circuits, particularly in the process of synaptic transmission. This protein is involved in cell-cell interactions within the nervous system, contributing to the regulation of neuronal communication. Like other members of the CASPR (Contactin-associated proteins) subfamily, Cntnap5c contains several extracellular domains that facilitate its binding with other proteins, particularly within synapses and at nodes of Ranvier, which are critical for proper electrical signal conduction along neurons. The inhibition of Cntnap5c would likely interfere with its ability to mediate these interactions, potentially leading to altered neuronal connectivity or disrupted signal transduction.
The design and study of Cntnap5c inhibitors require a detailed understanding of the protein's structure, its interaction sites, and the biological pathways it participates in. These inhibitors might target specific domains of the Cntnap5c protein, such as its extracellular or transmembrane domains, preventing its proper localization or interaction with other synaptic components. Inhibitors of this protein are of interest for their role in modulating the molecular dynamics of neuronal networks. The development of inhibitors relies on both structure-based drug design and high-throughput screening to identify compounds that can efficiently bind to Cntnap5c and inhibit its function without off-target effects on related neurexin family members.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin, a myosin II inhibitor, serves as a direct Cntnap5c inhibitor by disrupting actin-myosin interactions crucial for cell adhesion. This inhibition influences cellular morphology and adhesion processes mediated by Cntnap5c. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin, an HMG-CoA reductase inhibitor, indirectly influences Cntnap5c by disrupting the mevalonate pathway. This interference impacts membrane integrity, potentially affecting the localization and function of Cntnap5c as an integral membrane protein. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3-kinase inhibitor, serves as a direct Cntnap5c inhibitor by affecting phosphoinositide signaling. This inhibition disrupts cellular processes involved in cell adhesion, potentially modulating Cntnap5c function within the membrane. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM, a calcium chelator, indirectly influences Cntnap5c by disrupting intracellular calcium signaling. This interference impacts membrane-associated processes, potentially influencing the integral membrane localization and function of Cntnap5c. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a ROCK inhibitor, serves as a direct Cntnap5c inhibitor by disrupting actomyosin contractility. This inhibition influences cellular processes involved in cell adhesion, potentially modulating Cntnap5c function within the membrane. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A, an actin polymerization inhibitor, serves as a direct Cntnap5c inhibitor by disrupting actin dynamics. This inhibition influences cellular processes involved in cell adhesion, potentially modulating Cntnap5c function within the membrane. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542, a TGF-β receptor inhibitor, indirectly influences Cntnap5c by affecting TGF-β signaling. This interference impacts cellular processes involved in cell adhesion, potentially modulating Cntnap5c function within the membrane. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $193.00 $838.00 | 2 | |
GGTI-298, a geranylgeranyltransferase I inhibitor, serves as an indirect Cntnap5c inhibitor by affecting protein prenylation. This interference impacts membrane-associated processes, potentially influencing the integral membrane localization and function of Cntnap5c. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A, an ADP-ribosylation factor inhibitor, indirectly influences Cntnap5c by disrupting vesicular trafficking. This interference impacts membrane-associated processes, potentially influencing the integral membrane localization and function of Cntnap5c. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2, a Src family kinase inhibitor, serves as a direct Cntnap5c inhibitor by affecting tyrosine kinase signaling. This inhibition disrupts cellular processes involved in cell adhesion, potentially modulating Cntnap5c function within the membrane. | ||||||