Date published: 2025-10-20

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CLIP-115 Activators

CLIP-115 Activators encompass a diverse group of chemical compounds that indirectly but significantly potentiate the activity of CLIP-115 through varied and complex signaling pathways without affecting the protein's expression levels. For example, the PKC activator Phorbol 12-myristate 13-acetate (PMA) might indirectly promote CLIP-115 activity through PKC-mediated phosphorylation events, which can stabilize CLIP-115 or its associated proteins, thereby enhancing its functional role in the cytoskeleton dynamics. Similarly, Forskolin raises intracellular cAMP levels, subsequently activating PKA, which is known to phosphorylate a range of targets that could include regulators of CLIP-115, leading to its enhanced activity in neuronal cells. Staurosporine, despite its general kinase inhibition properties, can selectively relieve negative regulation on CLIP-115 by inhibiting upstream kinases that would otherwise suppress CLIP-115's functional roles, while EGCG's inhibition of various kinases could lead to a similar disinhibition of CLIP-115's activity by removing competitive or negative influences on its function.

The PI3K inhibitors LY294002 and Wortmannin indirectly enhance the activity of CLIP-115 by disrupting negative feedback within the PI3K/Akt pathway, which could otherwiseinhibit pathways that support CLIP-115. MEK1/2 inhibitor U0126 and p38 MAPK inhibitor SB203580 may enhance CLIP-115 activity by reducing signaling through competitive pathways that negatively impact CLIP-115 function. Sphingosine-1-phosphate enhances CLIP-115 by modulating sphingolipid signaling, which can positively influence the protein's role in the cytoskeleton. Furthermore, thapsigargin and A23187 (Calcimycin) increase intracellular calcium levels, which can activate calcium-dependent signaling pathways that enhance CLIP-115's role in neurons. Lastly, genistein may indirectly support CLIP-115's function by inhibiting tyrosine kinases and thus reducing competitive signaling, potentially favoring pathways that promote CLIP-115's activity in microtubule stabilization and dynamics.

SEE ALSO...

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA functions as a diacylglycerol analog and a potent activator of protein kinase C (PKC), which can indirectly enhance CLIP-115 activity by phosphorylating substrates that might interact with or stabilize CLIP-115, leading to its functional activation.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

This compound directly stimulates adenylyl cyclase, increasing cAMP levels, which activates PKA. PKA can then phosphorylate proteins that interact with or support CLIP-115 function in neuronal cells, thereby enhancing its activity.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

Although it is a broad-spectrum kinase inhibitor, staurosporine can selectively enhance CLIP-115 activity by inhibiting kinases that negatively regulate proteins associated with CLIP-115, thus promoting its function.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

EGCG acts as an inhibitor of various kinases and through this action, it could disinhibit certain pathways or proteins that suppress CLIP-115, leading to the enhanced activation of CLIP-115.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

As a PI3K inhibitor, LY294002 disrupts PI3K/Akt signaling, which might remove an inhibitory effect on a signaling cascade that supports CLIP-115 activity, indirectly enhancing its functional role.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

This p38 MAPK inhibitor may indirectly enhance CLIP-115 activity by skewing cellular signaling toward pathways that favor the function of CLIP-115, particularly in stress response.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin, another PI3K inhibitor, like LY294002, can enhance CLIP-115 activity by reducing negative regulatory effects of the PI3K/Akt pathway on proteins that work in concert with CLIP-115.

D-erythro-Sphingosine-1-phosphate

26993-30-6sc-201383
sc-201383D
sc-201383A
sc-201383B
sc-201383C
1 mg
2 mg
5 mg
10 mg
25 mg
$162.00
$316.00
$559.00
$889.00
$1693.00
7
(1)

Through modulating sphingolipid signaling, sphingosine-1-phosphate can promote signaling pathways that indirectly enhance the activity of CLIP-115 in cytoskeletal reorganization.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

As a SERCA pump inhibitor, thapsigargin raises intracellular calcium levels, which can activate calcium-dependent signaling pathways that subsequently enhance the functional role of CLIP-115 in neurons.

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$54.00
$128.00
$199.00
$311.00
23
(1)

A23187 acts as an ionophore that increases intracellular calcium concentration, thereby activating calcium-dependent pathways that can lead to the enhancement of CLIP-115 activity.