CLIP-115 Activators
CLIP-115 Activators encompass a diverse group of chemical compounds that indirectly but significantly potentiate the activity of CLIP-115 through varied and complex signaling pathways without affecting the protein's expression levels. For example, the PKC activator Phorbol 12-myristate 13-acetate (PMA) might indirectly promote CLIP-115 activity through PKC-mediated phosphorylation events, which can stabilize CLIP-115 or its associated proteins, thereby enhancing its functional role in the cytoskeleton dynamics. Similarly, Forskolin raises intracellular cAMP levels, subsequently activating PKA, which is known to phosphorylate a range of targets that could include regulators of CLIP-115, leading to its enhanced activity in neuronal cells. Staurosporine, despite its general kinase inhibition properties, can selectively relieve negative regulation on CLIP-115 by inhibiting upstream kinases that would otherwise suppress CLIP-115's functional roles, while EGCG's inhibition of various kinases could lead to a similar disinhibition of CLIP-115's activity by removing competitive or negative influences on its function.
The PI3K inhibitors LY294002 and Wortmannin indirectly enhance the activity of CLIP-115 by disrupting negative feedback within the PI3K/Akt pathway, which could otherwiseinhibit pathways that support CLIP-115. MEK1/2 inhibitor U0126 and p38 MAPK inhibitor SB203580 may enhance CLIP-115 activity by reducing signaling through competitive pathways that negatively impact CLIP-115 function. Sphingosine-1-phosphate enhances CLIP-115 by modulating sphingolipid signaling, which can positively influence the protein's role in the cytoskeleton. Furthermore, thapsigargin and A23187 (Calcimycin) increase intracellular calcium levels, which can activate calcium-dependent signaling pathways that enhance CLIP-115's role in neurons. Lastly, genistein may indirectly support CLIP-115's function by inhibiting tyrosine kinases and thus reducing competitive signaling, potentially favoring pathways that promote CLIP-115's activity in microtubule stabilization and dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA functions as a diacylglycerol analog and a potent activator of protein kinase C (PKC), which can indirectly enhance CLIP-115 activity by phosphorylating substrates that might interact with or stabilize CLIP-115, leading to its functional activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
This compound directly stimulates adenylyl cyclase, increasing cAMP levels, which activates PKA. PKA can then phosphorylate proteins that interact with or support CLIP-115 function in neuronal cells, thereby enhancing its activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Although it is a broad-spectrum kinase inhibitor, staurosporine can selectively enhance CLIP-115 activity by inhibiting kinases that negatively regulate proteins associated with CLIP-115, thus promoting its function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG acts as an inhibitor of various kinases and through this action, it could disinhibit certain pathways or proteins that suppress CLIP-115, leading to the enhanced activation of CLIP-115. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a PI3K inhibitor, LY294002 disrupts PI3K/Akt signaling, which might remove an inhibitory effect on a signaling cascade that supports CLIP-115 activity, indirectly enhancing its functional role. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This p38 MAPK inhibitor may indirectly enhance CLIP-115 activity by skewing cellular signaling toward pathways that favor the function of CLIP-115, particularly in stress response. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, another PI3K inhibitor, like LY294002, can enhance CLIP-115 activity by reducing negative regulatory effects of the PI3K/Akt pathway on proteins that work in concert with CLIP-115. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Through modulating sphingolipid signaling, sphingosine-1-phosphate can promote signaling pathways that indirectly enhance the activity of CLIP-115 in cytoskeletal reorganization. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
As a SERCA pump inhibitor, thapsigargin raises intracellular calcium levels, which can activate calcium-dependent signaling pathways that subsequently enhance the functional role of CLIP-115 in neurons. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as an ionophore that increases intracellular calcium concentration, thereby activating calcium-dependent pathways that can lead to the enhancement of CLIP-115 activity. | ||||||