CLIP-115 Inhibitors
Chemical inhibitors of CLIP-115 can effectively disrupt its function by targeting the microtubule dynamics that this protein is crucially involved with. Colchicine, for instance, inhibits microtubule polymerization, a process that is essential for the transport functions that CLIP-115 facilitates. By destabilizing microtubules, Colchicine prevents CLIP-115 from binding to them, which is necessary for its role in vesicle transport. Similarly, Nocodazole depolymerizes microtubules, thus impeding the microtubule-based transport system and consequently inhibiting the operational role of CLIP-115 within this system. Vinblastine and Vincristine also contribute to the inhibition of CLIP-115 by interfering with microtubule assembly. Their binding to tubulin obstructs microtubule formation, thereby impairing the ability of CLIP-115 to associate with and stabilize these cellular structures. Podophyllotoxin extends this inhibitory effect by blocking microtubule assembly, which is integral to CLIP-115's interaction with microtubules and its subsequent transport roles.
Further, chemicals like Eribulin and Peloruside A inhibit CLIP-115 by modulating microtubule dynamics differently. Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, which could disrupt the dynamic interaction required by CLIP-115 to function properly. Peloruside A stabilizes microtubules and, in doing so, possibly prevents the normal dynamic binding of CLIP-115, leading to its functional inhibition. The alteration of microtubule dynamics by Noscapine similarly inhibits CLIP-115 by impairing its proper interaction with microtubules. Thiabendazole and Albendazole further contribute to the inhibition of CLIP-115 by interfering with microtubule polymerization, thereby inhibiting the stabilizing activity of CLIP-115 and its function in microtubule-dependent processes. Griseofulvin adds to these effects by disrupting microtubule function through its interaction with tubulin, which is expected to inhibit the roles of CLIP-115 associated with microtubules. Through these various mechanisms, the selected chemicals can inhibit the functional role of CLIP-115 in the cellular transport system by directly affecting the microtubule structures and dynamics that CLIP-115 depends on.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine disrupts microtubule polymerization, which is critical for vesicle transport to which CLIP-115 contributes. Inhibiting microtubule dynamics can therefore inhibit the ability of CLIP-115 to bind to microtubules and perform its function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and as a result can prevent the proper functioning of microtubule-associated proteins like CLIP-115, which require dynamic microtubules to bind and unbind for their role in transport processes. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole depolymerizes microtubules, impeding the microtubule-based transport system where CLIP-115 operates, therefore functionally inhibiting the protein's role in the process. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine interferes with microtubule assembly, which can inhibit CLIP-115 function by disrupting the microtubules it associates with for cargo transport. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits microtubule assembly, which can block CLIP-115 function by preventing its interaction with microtubules, necessary for its role in cellular transport. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, potentially inhibiting the dynamic binding of CLIP-115 to microtubules, and thus its function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by interacting with tubulin, which can inhibit the microtubule-based transport roles of CLIP-115. | ||||||
Noscapine | 128-62-1 | sc-219418 | 10 mg | $102.00 | ||
Noscapine alters microtubule dynamics, which can inhibit the function of CLIP-115 by impairing its ability to interact with microtubules appropriately. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole interferes with microtubule polymerization, potentially inhibiting CLIP-115's microtubule-stabilizing activity, and thus its function in microtubule-based processes. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole disrupts microtubule polymerization, which can inhibit the function of CLIP-115 by impeding its role in the stabilization and interaction with microtubules. | ||||||