CLIP-115 Antibody (14): sc-135869

CLIP-115 Antibody (14) is a mouse monoclonal IgG1 kappa light chain antibody that detects CLIP-115 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-CLIP-115 antibody (14) is available as the non-conjugated format. CLIP-115 protein, encoded by the CYLN2 gene located in the Williams Syndrome critical region on chromosome 7q11.23, plays a crucial role in regulating microtubule dynamics, which is essential for maintaining cellular structure and facilitating intracellular transport. CLIP-115 protein is predominantly expressed in the brain, where CLIP-115 (14) monoclonal antibody contributes to neuronal stability and function. Disruptions in CLIP-115 expression can lead to significant neurological deficits, as observed in mouse models with haploinsufficiency of the CYLN2 gene, which exhibit symptoms similar to Williams Syndrome, including cognitive impairments and motor coordination challenges. CLIP-115 protein′s ability to bind to microtubules underscores its importance in neurodevelopment and highlights its potential as a target for understanding the underlying mechanisms of related disorders.

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CLIP-115 Antibody (14) References:

1. Williams syndrome: from genotype through to the cognitive phenotype.  |  Donnai, D. and Karmiloff-Smith, A. 2000. Am J Med Genet. 97: 164-71. PMID: 11180224
2. Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.  |  Hoogenraad, CC., et al. 2002. Nat Genet. 32: 116-27. PMID: 12195424
3. [Williams syndrome. A summary of cognitive, electrophysiological, anatomofunctional, microanatomical and genetic findings].  |  Galaburda, AM., et al. 2003. Rev Neurol. 36 Suppl 1: S132-7. PMID: 12599114
4. LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome.  |  Hoogenraad, CC., et al. 2004. Bioessays. 26: 141-50. PMID: 14745832
5. Functional, structural, and metabolic abnormalities of the hippocampal formation in Williams syndrome.  |  Meyer-Lindenberg, A., et al. 2005. J Clin Invest. 115: 1888-95. PMID: 15951840
6. Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviour.  |  Meyer-Lindenberg, A., et al. 2006. Nat Rev Neurosci. 7: 380-93. PMID: 16760918
7. The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region.  |  Hoogenraad, CC., et al. 1998. Genomics. 53: 348-58. PMID: 9799601

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CLIP-115 Antibody (14) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CLIP-115 Antibody (14) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CLIP-115 Antibody (14) Specifications

Alternate Product Name: CLIP-115

Product Clone Name: 14

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 801-917

Epitope Target: CLIP-115

Epitope Species: rat

Product Reactivity/Detection: CLIP-115

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CLIP-115 Antibody (14): N/A