CLEC-17A Activators
CLEC-17A can initiate a series of intracellular signaling cascades through various mechanisms, leading to the activation of this protein. Phorbol 12-myristate 13-acetate (PMA) and Bryostatin 1 directly activate protein kinase C (PKC), which plays a pivotal role in signaling pathways that result in CLEC-17A activation. This activation occurs via phosphorylation, a process where a phosphate group is added to CLEC-17A, thereby altering its function. Similarly, 1,2-Dioctanoyl-sn-glycerol (DiC8), a synthetic analog of diacylglycerol (DAG), also activates PKC, which in turn can lead to CLEC-17A activation. Ionomycin raises intracellular calcium levels, another trigger for PKC activation, suggesting a calcium-dependent route to CLEC-17A activation. Forskolin and Isoproterenol, on the other hand, raise intracellular levels of cAMP, which activates protein kinase A (PKA). PKA then can phosphorylate target proteins, leading to the activation of CLEC-17A through different signaling pathways.
Retinoic acid and Vitamin D3 modulate the activity of nuclear receptors that can influence gene expression patterns, indirectly affecting CLEC-17A activation. Prostaglandin E2 (PGE2) and Zaprinast increase cAMP levels, again implicating PKA in the signaling pathways leading to CLEC-17A activation. Lithium chloride's inhibition of glycogen synthase kinase 3 (GSK-3) may influence the Wnt signaling pathway, and indirectly lead to the activation of CLEC-17A as a part of this pathway's broad signaling effects. Lastly, Anisomycin, through its activation of stress-activated protein kinases (SAPKs) such as JNK, can initiate a stress response that culminates in the activation of CLEC-17A. Each of these chemicals initiates its own unique signaling pathway, but they converge on the common endpoint of CLEC-17A activation, albeit through different intermediate molecules and mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol esters like PMA directly activate protein kinase C (PKC), which is a known upstream activator of various cell signaling pathways, including those that lead to the activation of C-type lectin domain family 17, member A (CLEC-17A) through phosphorylation and subsequent signaling cascades. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin functions as a calcium ionophore, increasing intracellular calcium levels, which can activate PKC. The activation of PKC, in turn, activates CLEC-17A through downstream signaling pathways that depend on calcium-sensitive proteins and kinases. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 binds to and modulates PKC, which can lead to the activation of CLEC-17A by triggering protein phosphorylation and modifications that activate signaling pathways CLEC-17A is involved in. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
DiC8 is a synthetic analog of diacylglycerol (DAG), which is a PKC activator. By activating PKC, DiC8 promotes phosphorylation events that could lead to the activation of CLEC-17A. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, thereby activating PKA. The activation of PKA potentially leads to the activation of CLEC-17A by phosphorylating proteins in the signaling pathway CLEC-17A is part of. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can influence cell differentiation and modulate the activity of nuclear receptors. Through the activation of specific transcription factors, retinoic acid may promote the activation of signaling pathways that include CLEC-17A. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 through its active form, calcitriol, binds to the vitamin D receptor (VDR), which may activate signaling pathways that include CLEC-17A, as VDR can regulate the expression of various proteins involved in immune response. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 interacts with its receptors, leading to increased intracellular cAMP levels, which activate PKA. PKA activation can lead to the activation of CLEC-17A as part of the signal transduction pathways it influences. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits phosphodiesterase 5, leading to increased cAMP levels in cells, which activates PKA. Activation of PKA can lead to downstream signaling events that activate CLEC-17A. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3). Inhibition of GSK-3 can lead to the activation of Wnt signaling pathway, resulting in the activation of CLEC-17A as part of the complex signaling cascade. | ||||||