Date published: 2025-10-16

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CIZ1 Inhibitors

CIZ1 inhibitors refer to a category of chemical compounds or molecules designed to specifically target and modulate the activity of the cellular cyclin-dependent kinase inhibitor 1 (CIZ1) protein. CIZ1, a nuclear matrix-associated protein, plays a role in regulating cell cycle progression, DNA replication, and RNA processing. The inhibition of CIZ1 is of particular interest in research settings, as it allows scientists to investigate the cellular mechanisms influenced by CIZ1. These inhibitors are developed through various chemical synthesis and structural optimization techniques, aiming to interact with specific domains or functional motifs of the CIZ1 protein to disrupt its normal function.

The design of CIZ1 inhibitors involves creating molecules with the ability to selectively bind to CIZ1 and interfere with its interactions with other cellular components, such as DNA, RNA, and other proteins. By doing so, CIZ1 inhibitors can affect key cellular processes regulated by CIZ1, including DNA replication, transcription, and cell cycle control. This research enables scientists to delve deeper into the intricate molecular mechanisms underlying these cellular functions and to gain a better understanding of the role played by CIZ1 in normal cellular physiology. The study of CIZ1 inhibitors is a valuable avenue for advancing our knowledge of fundamental cell biology and the regulatory networks governing processes such as cell division and DNA replication.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Doxorubicin

23214-92-8sc-280681
sc-280681A
1 mg
5 mg
$173.00
$418.00
43
(3)

An anthracycline compound that intercalates DNA and inhibits topoisomerase II, potentially affecting the expression of DNA replication-related proteins like CIZ1.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$32.00
$170.00
$385.00
63
(1)

A topoisomerase II inhibitor, etoposide can disrupt DNA replication and repair mechanisms, potentially influencing CIZ1 expression.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$36.00
$149.00
11
(1)

As an antimetabolite, 5-FU inhibits thymidylate synthase, affecting DNA synthesis and potentially impacting CIZ1 expression.

Taxol

33069-62-4sc-201439D
sc-201439
sc-201439A
sc-201439E
sc-201439B
sc-201439C
1 mg
5 mg
25 mg
100 mg
250 mg
1 g
$40.00
$73.00
$217.00
$242.00
$724.00
$1196.00
39
(2)

A microtubule stabilizer, paclitaxel disrupts mitotic spindle function, which could indirectly affect proteins involved in cell cycle regulation like CIZ1.

Camptothecin

7689-03-4sc-200871
sc-200871A
sc-200871B
50 mg
250 mg
100 mg
$57.00
$182.00
$92.00
21
(2)

An inhibitor of topoisomerase I, camptothecin disrupts DNA replication, potentially influencing CIZ1 expression.

Cisplatin

15663-27-1sc-200896
sc-200896A
100 mg
500 mg
$76.00
$216.00
101
(4)

A platinum-based chemotherapy agent, cisplatin forms DNA adducts, potentially affecting the expression of DNA replication proteins.

Methotrexate

59-05-2sc-3507
sc-3507A
100 mg
500 mg
$92.00
$209.00
33
(5)

As a dihydrofolate reductase inhibitor, methotrexate affects nucleotide synthesis and may indirectly influence CIZ1 expression.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

A proteasome inhibitor, bortezomib can affect various cellular pathways, potentially influencing the expression of proteins involved in cell cycle.

Vinblastine

865-21-4sc-491749
sc-491749A
sc-491749B
sc-491749C
sc-491749D
10 mg
50 mg
100 mg
500 mg
1 g
$100.00
$230.00
$450.00
$1715.00
$2900.00
4
(0)

A vinca alkaloid that inhibits microtubule formation, vinblastine can disrupt cell division, potentially affecting CIZ1 expression.

Bleomycin

11056-06-7sc-507293
5 mg
$270.00
5
(0)

Acts by causing DNA breaks; might influence the expression of proteins involved in DNA replication and repair, like CIZ1.