CIZ1 inhibitors refer to a category of chemical compounds or molecules designed to specifically target and modulate the activity of the cellular cyclin-dependent kinase inhibitor 1 (CIZ1) protein. CIZ1, a nuclear matrix-associated protein, plays a role in regulating cell cycle progression, DNA replication, and RNA processing. The inhibition of CIZ1 is of particular interest in research settings, as it allows scientists to investigate the cellular mechanisms influenced by CIZ1. These inhibitors are developed through various chemical synthesis and structural optimization techniques, aiming to interact with specific domains or functional motifs of the CIZ1 protein to disrupt its normal function.
The design of CIZ1 inhibitors involves creating molecules with the ability to selectively bind to CIZ1 and interfere with its interactions with other cellular components, such as DNA, RNA, and other proteins. By doing so, CIZ1 inhibitors can affect key cellular processes regulated by CIZ1, including DNA replication, transcription, and cell cycle control. This research enables scientists to delve deeper into the intricate molecular mechanisms underlying these cellular functions and to gain a better understanding of the role played by CIZ1 in normal cellular physiology. The study of CIZ1 inhibitors is a valuable avenue for advancing our knowledge of fundamental cell biology and the regulatory networks governing processes such as cell division and DNA replication.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
An anthracycline compound that intercalates DNA and inhibits topoisomerase II, potentially affecting the expression of DNA replication-related proteins like CIZ1. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
A topoisomerase II inhibitor, etoposide can disrupt DNA replication and repair mechanisms, potentially influencing CIZ1 expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
As an antimetabolite, 5-FU inhibits thymidylate synthase, affecting DNA synthesis and potentially impacting CIZ1 expression. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
A microtubule stabilizer, paclitaxel disrupts mitotic spindle function, which could indirectly affect proteins involved in cell cycle regulation like CIZ1. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
An inhibitor of topoisomerase I, camptothecin disrupts DNA replication, potentially influencing CIZ1 expression. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
A platinum-based chemotherapy agent, cisplatin forms DNA adducts, potentially affecting the expression of DNA replication proteins. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
As a dihydrofolate reductase inhibitor, methotrexate affects nucleotide synthesis and may indirectly influence CIZ1 expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor, bortezomib can affect various cellular pathways, potentially influencing the expression of proteins involved in cell cycle. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
A vinca alkaloid that inhibits microtubule formation, vinblastine can disrupt cell division, potentially affecting CIZ1 expression. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Acts by causing DNA breaks; might influence the expression of proteins involved in DNA replication and repair, like CIZ1. |