CIZ1 Activators
CIZ1 Activators are a select group of chemical compounds that facilitate the enhancement of CIZ1 function through various biochemical pathways. For instance, Forskolin and Rolipram both raise intracellular cAMP levels, indirectly promoting CIZ1 activity by augmenting PKA, which may phosphorylate substrates involved in DNA replication and cell cycle control, processes where CIZ1 is a key participant. Similarly, Epigallocatechin gallate (EGCG) and Resveratrol modulate kinases and sirtuins, respectively, reducing competitive signaling and allowing CIZ1 to perform its role in maintaining nuclear integrity and supporting DNA repair mechanisms more effectively. Ionomycin, by increasing intracellular calcium, could activate kinases that phosphorylate CIZ1, enhancing its nuclear functions. Spermidine, through its role in autophagy, may indirectly support the structural role of CIZ1 during cell division.
Furthermore, the activity of CIZ1 within the cellular milieu is influenced by compounds that target various signaling molecules and pathways. AICAR, by activating AMPK, may enhance CIZ1 activity related to cellular energy homeostasis and DNA replication. PD98059 and SB203580 alter MAPK signaling pathways, shifting the balance to favor CIZ1's role in the cell cycle and DNA repair without upregulating its expressionor direct activation. Trichostatin A, through its influence on chromatin dynamics, could facilitate CIZ1's engagement with the replication machinery of the cell. Lastly, ZM-447439's inhibition of Aurora kinases could create a cellular environment that indirectly enhances the activity of CIZ1 in mitotic processes. These activators, through their interactions with various signaling pathways and molecules, collectively contribute to the functional enhancement of CIZ1, emphasizing its role in critical cellular functions such as DNA replication, cell cycle progression, and the maintenance of nuclear architecture.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP enhances protein kinase A (PKA) activity, which could potentially phosphorylate CIZ1, thus increasing its functional activity in the cell cycle control and DNA replication. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein kinases, potentially decreasing competitive signaling and allowing for the preferential activation of CIZ1-associated pathways involved in nuclear architecture and function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3K, LY294002, could enhance CIZ1 function by altering PI3K/Akt signaling pathways, which are involved in cell growth and survival, thereby indirectly affecting CIZ1's role in DNA replication. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
As a sirtuin activator, Resveratrol could enhance CIZ1 function by modulating the activity of proteins involved in DNA repair and replication, given CIZ1's involvement in these processes. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram, a phosphodiesterase inhibitor, increases cAMP levels, similarly to Forskolin, potentially enhancing PKA activity and consequently CIZ1 function related to cell cycle progression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which could activate calcium-dependent kinases that phosphorylate and increase the activity of CIZ1 in the nucleus. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is known to induce autophagy and may modulate nuclear architecture. This could indirectly enhance CIZ1's role in maintaining nuclear structure during cell division. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK) and might enhance CIZ1 activity by influencing cellular energy balance and DNA replication processes where CIZ1 is implicated. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK, PD98059, might indirectly increase CIZ1 activity by altering the MAPK/ERK pathway, which is involved in cell cycle and growth, thereby affecting CIZ1's role in these processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, which might shift signaling dynamics in favor of pathways where CIZ1 is active, particularly in stress response and DNA damage repair. | ||||||