Chx10 Inhibitors
Chx10 inhibitors belong to a specific class of chemical compounds that are designed to modulate the activity of the Chx10 gene or protein. Chx10, also known as Visual System Homeobox 2 (VSX2), is a critical transcription factor that plays a fundamental role in the development and maintenance of various tissues within the eye, including the retina. These inhibitors are designed to target Chx10 and regulate its function, often by interfering with its binding to specific DNA sequences or by affecting its interactions with other proteins in the signaling pathways.
Chx10 inhibitors are of particular interest in the field of molecular biology and ophthalmology research because of their ability to elucidate the intricate processes involved in eye development and function. By inhibiting Chx10, researchers can explore its downstream effects on gene expression and cellular differentiation, shedding light on the molecular mechanisms that underlie various eye-related disorders and diseases. Additionally, these inhibitors can serve as valuable tools for studying retinal development, regeneration, and cell fate determination in experimental settings. Overall, Chx10 inhibitors offer a means to explore the intricate regulatory networks governing eye development and function, contributing to our understanding of ocular biology and informing future research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is a pyrimidine analog that can incorporate into RNA and DNA, potentially leading to errors in gene expression and inhibition of protein synthesis, which might downregulate Chx10 expression. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin hydrochloride intercalates with DNA and disrupts topoisomerase-II-mediated DNA repair, leading to alterations in gene expression and potentially decreasing Chx10 expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is a folate analog that inhibits dihydrofolate reductase, leading to reduced nucleotide synthesis and potentially hindering Chx10 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a cytidine analog that can be incorporated into DNA and RNA, leading to hypomethylation of DNA and potentially downregulating Chx10 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine might affect gene expression patterns and decrease Chx10 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and inhibits RNA polymerase, potentially decreasing the transcription of various genes, including Chx10. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, leading to changes in chromatin structure and potentially downregulating Chx10 expression. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms DNA adducts and induces DNA damage, potentially altering gene expression patterns and decreasing Chx10 expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to decreased DNA synthesis and potentially downregulating Chx10 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid is a histone deacetylase inhibitor, potentially leading to chromatin remodeling and decreased Chx10 expression. | ||||||