Ces1a Inhibitors
Ces1a, identified as carboxylesterase 1A, is a crucial enzyme predicted to play a key role in sterol esterase activity. The gene is intricately involved in cellular responses to cholesterol, cholesterol homeostasis, and the regulation of steroid metabolic processes. Located in the cytoplasm and predicted to be active in the endoplasmic reticulum and lipid droplets, Ces1a exhibits tissue-specific expression, particularly in the testis. This gene shares orthologous relationships with human CES1, underlining its evolutionary conservation and functional significance in maintaining lipid homeostasis.
Inhibition of Ces1a involves the utilization of various chemical compounds that directly or indirectly impact its predicted functions. Several sterol esterase inhibitors, such as Orlistat and Tetrahydrolipstatin, directly target Ces1a, blocking its sterol esterase activity and disrupting cellular responses to cholesterol. Indirect inhibitors, such as Lovastatin and GW3965, modulate cholesterol homeostasis, influencing Ces1a's functions in response to cholesterol and regulation of steroid metabolic processes. Other compounds, like TOFA and Bezafibrate, impact lipid metabolism, demonstrating the diverse strategies employed to inhibit Ces1a. The general mechanisms of Ces1a inhibition revolve around disrupting its predicted functions in sterol esterase activity and cholesterol homeostasis. Direct inhibitors interfere with the enzymatic activity of Ces1a, while indirect inhibitors modulate cellular processes associated with Ces1a's functions. These mechanisms highlight the intricate balance maintained by Ces1a in cellular lipid homeostasis. Understanding Ces1a and its inhibition provides insights into the complex interplay between lipid metabolism and cellular responses to cholesterol, offering a foundation for further exploration of strategies targeting lipid-related disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipase Inhibitor, THL | 96829-58-2 | sc-203108 | 50 mg | $51.00 | 7 | |
By blocking the hydrolysis of sterol esters, THL disrupts the cellular response to cholesterol and cholesterol homeostasis, inhibiting Ces1a's involvement in these processes. | ||||||
GW 4064 | 278779-30-9 | sc-218577 | 5 mg | $93.00 | 13 | |
GW4064, an FXR (farnesoid X receptor) agonist, indirectly inhibits Ces1a by influencing cellular responses to cholesterol. Through FXR activation, GW4064 modulates cholesterol homeostasis, potentially suppressing Ces1a's function in this context. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin, an HMG-CoA reductase inhibitor, indirectly inhibits Ces1a by impacting cholesterol homeostasis. By blocking the mevalonate pathway, Lovastatin reduces cellular cholesterol levels, potentially altering Ces1a's activity in response to cholesterol and influencing its role in regulating steroid metabolic processes. | ||||||
Avasimibe | 166518-60-1 | sc-364315 sc-364315A sc-364315B sc-364315C | 10 mg 50 mg 500 mg 1 g | $107.00 $413.00 $2040.00 $3060.00 | 1 | |
cholesterol acyltransferase) inhibitor, affects Ces1a's role in cholesterol homeostasis. By preventing cholesterol esterification, Avasimibe indirectly inhibits Ces1a's predicted sterol esterase activity, influencing cellular responses to cholesterol and regulation of steroid metabolic processes. | ||||||
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $137.00 $474.00 $3060.00 | ||
GW3965, an LXR (liver X receptor) agonist, indirectly modulates Ces1a by influencing cholesterol homeostasis. LXR activation by GW3965 may impact Ces1a's function in cellular responses to cholesterol, altering its role in maintaining cholesterol balance and regulating steroid metabolic processes. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin, another HMG-CoA reductase inhibitor, indirectly inhibits Ces1a by perturbing cholesterol homeostasis. By interfering with the mevalonate pathway, Simvastatin reduces cellular cholesterol levels, potentially impacting Ces1a's function in cellular responses to cholesterol and regulation of steroid metabolic processes. | ||||||
TEMPOL | 2226-96-2 | sc-200825 | 1 g | $36.00 | 33 | |
TEMPOL influences Ces1a's predicted involvement in cellular responses to cholesterol. By inhibiting ACC, TOFA may modulate lipid metabolism, indirectly impacting Ces1a's function in cholesterol homeostasis and regulation of steroid metabolic processes. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid, a natural compound, indirectly influences Ces1a by modulating cholesterol homeostasis. Its potential impact on lipid metabolism may alter Ces1a's function in cellular responses to cholesterol and the regulation of steroid metabolic processes. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $65.00 $262.00 | 2 | |
Gemfibrozil, a PPAR-alpha agonist, indirectly modulates Ces1a by affecting cellular responses to cholesterol. By activating PPAR-alpha, Gemfibrozil may influence Ces1a's role in cholesterol homeostasis and the regulation of steroid metabolic processes, demonstrating an indirect mechanism of inhibition. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate, another PPAR-alpha agonist, indirectly influences Ces1a by modulating cholesterol homeostasis. Through PPAR-alpha activation, Bezafibrate may impact Ces1a's function in cellular responses to cholesterol and the regulation of steroid metabolic processes, demonstrating an indirect mechanism of inhibition. | ||||||