Ces1a Activators
Ces1a, known as carboxylesterase 1A, emerges as a crucial player in cellular processes dedicated to sterol esterase activity. Predicted to contribute to the cellular response to cholesterol, cholesterol homeostasis, and the regulation of steroid metabolic processes, Ces1a exhibits a versatile role within the cellular landscape. Positioned predominantly in the cytoplasm and endoplasmic reticulum, with activity extending to lipid droplets, Ces1a's expression in testis underscores its relevance in specific reproductive contexts. Its predicted functions highlight a sophisticated involvement in maintaining cellular cholesterol balance, crucial for various cellular processes and homeostatic regulation.
The activation of Ces1a involves a diverse array of chemical activators that intricately modulate its activity. These activators, whether direct or indirect, influence the sterol esterase activity of Ces1a, contributing to cellular responses associated with cholesterol metabolism. Direct activators facilitate the up-regulation of Ces1a, enhancing its role in cholesterol homeostasis and the cellular response to cholesterol. Meanwhile, indirect activators, by influencing various cellular pathways, pathways such as lipid metabolism, cholesterol biosynthesis, and PPAR activation, contribute to the overall activation of Ces1a. This intricate network of chemical modulators ensures the precise orchestration of Ces1a's functions, emphasizing its significance in maintaining cellular health and metabolic balance. The cytoplasmic and endoplasmic reticular localization of Ces1a, coupled with its involvement in lipid droplets, further accentuates its role in cellular compartments crucial for metabolic processes, underlining its importance in cellular physiology. Ces1a's multifaceted functions and the intricate mechanisms of activation collectively emphasize its significance in cellular processes related to cholesterol metabolism and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $137.00 $474.00 $3060.00 | ||
GW3965 is a direct activator of Ces1a, up-regulating sterol esterase activity. It directly influences cholesterol homeostasis, triggering Ces1a activation in the cytoplasm and endoplasmic reticulum, contributing to the cellular response to cholesterol and regulation of steroid metabolic processes. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate serves as a direct activator by stimulating PPARα, enhancing Ces1a activity in lipid droplets and the endoplasmic reticulum. This up-regulates sterol esterase activity, influencing cholesterol homeostasis and the cellular response to cholesterol in testis, where Ces1a is expressed. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid acts as an indirect activator by modulating lipid metabolism pathways. It indirectly up-regulates Ces1a, influencing sterol esterase activity and contributing to cholesterol homeostasis and the cellular response to cholesterol in the cytoplasm and endoplasmic reticulum. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate serves as a direct activator by stimulating PPARα, enhancing Ces1a activity in lipid droplets and the endoplasmic reticulum. This up-regulates sterol esterase activity, influencing cholesterol homeostasis and the cellular response to cholesterol in testis, where Ces1a is expressed. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin indirectly activates Ces1a by inhibiting HMG-CoA reductase. This leads to the up-regulation of Ces1a, influencing sterol esterase activity and contributing to cholesterol homeostasis and the cellular response to cholesterol in the cytoplasm and endoplasmic reticulum. | ||||||
Avasimibe | 166518-60-1 | sc-364315 sc-364315A sc-364315B sc-364315C | 10 mg 50 mg 500 mg 1 g | $107.00 $413.00 $2040.00 $3060.00 | 1 | |
Avasimibe is a direct activator of Ces1a, enhancing sterol esterase activity. It directly influences cholesterol homeostasis, triggering Ces1a activation in the cytoplasm and endoplasmic reticulum, contributing to the cellular response to cholesterol and regulation of steroid metabolic processes. | ||||||
22(R)-hydroxycholesterol | 17954-98-2 | sc-205106 sc-205106A sc-205106B | 1 mg 5 mg 10 mg | $108.00 $350.00 $600.00 | 1 | |
22(R)-hydroxycholesterol serves as an indirect activator by modulating the cholesterol biosynthesis pathway. It indirectly up-regulates Ces1a, influencing sterol esterase activity and contributing to cholesterol homeostasis and the cellular response to cholesterol in the cytoplasm and endoplasmic reticulum. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone is a direct activator of Ces1a, up-regulating sterol esterase activity. It directly influences cholesterol homeostasis, triggering Ces1a activation in the cytoplasm and endoplasmic reticulum, contributing to the cellular response to cholesterol and regulation of steroid metabolic processes. | ||||||
Pravastatin, Sodium Salt | 81131-70-6 | sc-203218 sc-203218A sc-203218B | 25 mg 100 mg 1 g | $68.00 $159.00 $772.00 | 2 | |
Pravastatin, Sodium Salt indirectly activates Ces1a by inhibiting HMG-CoA reductase. This leads to the up-regulation of Ces1a, influencing sterol esterase activity and contributing to cholesterol homeostasis and the cellular response to cholesterol in the cytoplasm and endoplasmic reticulum. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516 serves as a direct activator by stimulating PPARδ, enhancing Ces1a activity in lipid droplets and the endoplasmic reticulum. This up-regulates sterol esterase activity, influencing cholesterol homeostasis and the cellular response to cholesterol in testis, where Ces1a is expressed. | ||||||