Date published: 2025-10-19

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Ces1a Activators

Ces1a, known as carboxylesterase 1A, emerges as a crucial player in cellular processes dedicated to sterol esterase activity. Predicted to contribute to the cellular response to cholesterol, cholesterol homeostasis, and the regulation of steroid metabolic processes, Ces1a exhibits a versatile role within the cellular landscape. Positioned predominantly in the cytoplasm and endoplasmic reticulum, with activity extending to lipid droplets, Ces1a's expression in testis underscores its relevance in specific reproductive contexts. Its predicted functions highlight a sophisticated involvement in maintaining cellular cholesterol balance, crucial for various cellular processes and homeostatic regulation.

The activation of Ces1a involves a diverse array of chemical activators that intricately modulate its activity. These activators, whether direct or indirect, influence the sterol esterase activity of Ces1a, contributing to cellular responses associated with cholesterol metabolism. Direct activators facilitate the up-regulation of Ces1a, enhancing its role in cholesterol homeostasis and the cellular response to cholesterol. Meanwhile, indirect activators, by influencing various cellular pathways, pathways such as lipid metabolism, cholesterol biosynthesis, and PPAR activation, contribute to the overall activation of Ces1a. This intricate network of chemical modulators ensures the precise orchestration of Ces1a's functions, emphasizing its significance in maintaining cellular health and metabolic balance. The cytoplasmic and endoplasmic reticular localization of Ces1a, coupled with its involvement in lipid droplets, further accentuates its role in cellular compartments crucial for metabolic processes, underlining its importance in cellular physiology. Ces1a's multifaceted functions and the intricate mechanisms of activation collectively emphasize its significance in cellular processes related to cholesterol metabolism and homeostasis.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

GW 3965 hydrochloride

405911-17-3sc-224011
sc-224011A
sc-224011B
5 mg
25 mg
1 g
$137.00
$474.00
$3060.00
(1)

GW3965 is a direct activator of Ces1a, up-regulating sterol esterase activity. It directly influences cholesterol homeostasis, triggering Ces1a activation in the cytoplasm and endoplasmic reticulum, contributing to the cellular response to cholesterol and regulation of steroid metabolic processes.

Bezafibrate

41859-67-0sc-204650B
sc-204650
sc-204650A
sc-204650C
500 mg
1 g
5 g
10 g
$30.00
$45.00
$120.00
$200.00
5
(1)

Bezafibrate serves as a direct activator by stimulating PPARα, enhancing Ces1a activity in lipid droplets and the endoplasmic reticulum. This up-regulates sterol esterase activity, influencing cholesterol homeostasis and the cellular response to cholesterol in testis, where Ces1a is expressed.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic Acid acts as an indirect activator by modulating lipid metabolism pathways. It indirectly up-regulates Ces1a, influencing sterol esterase activity and contributing to cholesterol homeostasis and the cellular response to cholesterol in the cytoplasm and endoplasmic reticulum.

Fenofibrate

49562-28-9sc-204751
5 g
$40.00
9
(1)

Fenofibrate serves as a direct activator by stimulating PPARα, enhancing Ces1a activity in lipid droplets and the endoplasmic reticulum. This up-regulates sterol esterase activity, influencing cholesterol homeostasis and the cellular response to cholesterol in testis, where Ces1a is expressed.

Lovastatin

75330-75-5sc-200850
sc-200850A
sc-200850B
5 mg
25 mg
100 mg
$28.00
$88.00
$332.00
12
(1)

Lovastatin indirectly activates Ces1a by inhibiting HMG-CoA reductase. This leads to the up-regulation of Ces1a, influencing sterol esterase activity and contributing to cholesterol homeostasis and the cellular response to cholesterol in the cytoplasm and endoplasmic reticulum.

Avasimibe

166518-60-1sc-364315
sc-364315A
sc-364315B
sc-364315C
10 mg
50 mg
500 mg
1 g
$107.00
$413.00
$2040.00
$3060.00
1
(0)

Avasimibe is a direct activator of Ces1a, enhancing sterol esterase activity. It directly influences cholesterol homeostasis, triggering Ces1a activation in the cytoplasm and endoplasmic reticulum, contributing to the cellular response to cholesterol and regulation of steroid metabolic processes.

22(R)-hydroxycholesterol

17954-98-2sc-205106
sc-205106A
sc-205106B
1 mg
5 mg
10 mg
$108.00
$350.00
$600.00
1
(1)

22(R)-hydroxycholesterol serves as an indirect activator by modulating the cholesterol biosynthesis pathway. It indirectly up-regulates Ces1a, influencing sterol esterase activity and contributing to cholesterol homeostasis and the cellular response to cholesterol in the cytoplasm and endoplasmic reticulum.

Troglitazone

97322-87-7sc-200904
sc-200904B
sc-200904A
5 mg
10 mg
25 mg
$108.00
$200.00
$426.00
9
(1)

Troglitazone is a direct activator of Ces1a, up-regulating sterol esterase activity. It directly influences cholesterol homeostasis, triggering Ces1a activation in the cytoplasm and endoplasmic reticulum, contributing to the cellular response to cholesterol and regulation of steroid metabolic processes.

Pravastatin, Sodium Salt

81131-70-6sc-203218
sc-203218A
sc-203218B
25 mg
100 mg
1 g
$68.00
$159.00
$772.00
2
(1)

Pravastatin, Sodium Salt indirectly activates Ces1a by inhibiting HMG-CoA reductase. This leads to the up-regulation of Ces1a, influencing sterol esterase activity and contributing to cholesterol homeostasis and the cellular response to cholesterol in the cytoplasm and endoplasmic reticulum.

GW501516

317318-70-0sc-202642
sc-202642A
1 mg
5 mg
$80.00
$175.00
28
(3)

GW501516 serves as a direct activator by stimulating PPARδ, enhancing Ces1a activity in lipid droplets and the endoplasmic reticulum. This up-regulates sterol esterase activity, influencing cholesterol homeostasis and the cellular response to cholesterol in testis, where Ces1a is expressed.