Troglitazone CAS: 97322-87-7
MF: C24H27NO5S
MW: 441.5
A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent.

Troglitazone (CAS 97322-87-7)

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Application A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent
CAS 등록번호: 97322-87-7
순도: ≥98%
분자량: 441.5
분자식: C24H27NO5S
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Troglitazone has been shown to be a potent antiproliferative and apoptosis inducer. This compound has displayed a capacity to inhibit growth of HCC cells via G1 phase cell cycle arrest through hypophosphorylation of Rb (retinoblastoma) protein and an increase of the cyclin-dependent kinase inhibitors, p21 and p27 proteins. In addition, Troglitazone has been reported to have profound antioxidant and antiinflammatory effects, and found to suppress L-type and receptor operated Ca2+ channel and PKC (protein kinase C). Experiments have shown Troglitazone to bind and activate PPARγ(peroxisome proliferator-activated receptor γ). PPARγ is mainly expressed in adipose tissue, one of the target tissues for insulin, but has subsequently been found to be expressed in vascular smooth muscle cells, endothelial cells, macrophages, and some cancer cells.


References

1. Tsubouchi, Y., et al. 2000. Biochem. Biophys. Res. Commun. 270: 400-405. PMID: 10753637
2. Okura, T., et al. 2000. Eur. J. Pharmacol. 407: 227-235. PMID: 11068018
3. Fujiwara, T., et al. 2000. Life Sci. 67: 2405-2416. PMID: 11065164
4. Aljada, A., et al. 2001. J. Clin. Endocrinol. Metab. 86: 3250-3256. PMID: 11443197
5. Berger, J., et al. 2002. Annu. Rev. Med. 53: 409-435. PMID: 11818483
6. Yoshizawa, K., et al. 2002. Cancer. 95: 2243-2251. PMID: 12412180

Physical State :
Solid
용해도 :
Soluble in ethanol (>25 mg/ml) at 50° C, DMSO (>25 mg/ml), DMF (30 mg/ml), DMSO:PBS (1:6, pH 7.2) (0.1 mg/ml), and water (0.1 mg/ml) at 25° C.
저장 :
Store at -20° C
녹는점 :
312.54° C (Predicted)
비등점 :
~657.0° C at 760 mmHg (Predicted)
밀도 :
~1.3 g/cm3 (Predicted)
굴절률 :
n20D 1.61 (Predicted)
IC50 :
Stimulatin PPARγg glucose transport: EC5050 = 1 µM (adipocytes); PPARγ: EC5050 = 780 nM (murine); PPARγ: EC5050 = 555 nM (human); Induces cell cycle arrest and apoptosis: EC5050 = 10 µM (cancer cell lines); Monoamine oxidase B: IC50 = 2.07 µM (human)
Ki 데이타 :
Peroxisome proliferator-activated receptor gamma: Ki= 3.8 µM (human)
pK Values :
pKa: 6.35 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
2
RTECS :
XJ5813130
PubChem CID :
5591
Merck Index :
14: 9769
MDL Number :
MFCD00878416
SMILES :
CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O

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Troglitazone  논문정보

다른 사용자의 Troglitazone사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 5 of {3} total

PMID: # 31416829  2019. Biochem. J. 476: 2427-2447.

PMID: # 26313919  Myneni, VD. et al. 2015. Cell death & disease. 6: e1868.

PMID: # 24910239  Penner, N. et al. 2014. Drug Metab Lett. 8: 36-42.

PMID: # 22981620  Kim, JA. et al. 2012. Toxicology letters. 214: 175-81.

PMID: # 22365411  Kim, Y. et al. 2012. Eur J Med Chem. 50: 311-8.

Citations 1 to 5 of {3} total
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