CENP-B Inhibitors

CENP-B inhibitors are a class of chemical compounds that target a specific protein known as Centromere Protein B (CENP-B). CENP-B is a crucial component of the centromere, a specialized region on chromosomes that plays a pivotal role in cell division and chromosome segregation. The centromere ensures that genetic material is distributed accurately to daughter cells during cell division. CENP-B itself is essential for maintaining the structural integrity and function of the centromere. Its primary role is to bind to a specific DNA sequence within the centromere known as the CENP-B box, which helps organize and stabilize the kinetochore, a protein complex that attaches to spindle fibers and facilitates chromosome movement during mitosis and meiosis.

CENP-B inhibitors are designed to interfere with the interaction between CENP-B and the CENP-B box DNA sequence. By disrupting this binding, these inhibitors disrupt the proper assembly and function of the centromere and kinetochore, leading to errors in chromosome segregation during cell division. This disruption can have significant consequences for cell viability and genomic stability. Researchers have been exploring CENP-B inhibitors as valuable tools in understanding the fundamental processes of cell division and chromosome segregation, shedding light on the intricate molecular mechanisms involved. Additionally, these inhibitors are used in various research contexts, such as in studies investigating the regulation of centromere function and the development of novel approaches for manipulating chromosome behavior in a controlled manner.