CELSR3 Activators
CELSR3 activators include a range of chemical compounds that facilitate the planar cell polarity (PCP) pathway, where CELSR3 is directly involved. Forskolin, Rolipram, Epinephrine, Caffeine, Dopamine, Histamine, Serotonin, Norepinephrine, IBMX, Isoproterenol, Salbutamol, and Terbutaline all enhance the levels of cAMP, a second messenger that activates protein kinase A (PKA). PKA then phosphorylates Dishevelled (Dsh/Dvl) proteins, a key process in the PCP pathway. By enhancing the phosphorylation of Dsh/Dvl proteins, these chemicals indirectly enhance the functional activity of CELSR3, a key player in this pathway.
Most of these compounds, such as Forskolin andRolipram, act by activating adenylyl cyclase or inhibiting phosphodiesterase, enzymes that respectively synthesize and degrade cAMP. This results in a net increase in cAMP levels, which leads to the activation of PKA. Other compounds, like Epinephrine, Dopamine, Histamine, Serotonin, Norepinephrine, Isoproterenol, Salbutamol, and Terbutaline, are neurotransmitters or drugs that bind to specific receptors, leading to the activation of adenylyl cyclase through G-protein coupled receptor signaling. The resultant increase in cAMP levels promotes PKA activity. The activated PKA phosphorylates Dsh/Dvl proteins, a crucial step in the PCP pathway, leading to the enhanced functional activity of CELSR3. These specific biochemical mechanisms underline the indirect activation of CELSR3 by these chemical compounds.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, an enzyme that increases the levels of cyclic adenosine monophosphate (cAMP). The raised cAMP levels can activate Protein Kinase A (PKA) which in turn phosphorylates Dishevelled (Dsh/Dvl) proteins, key components in the planar cell polarity (PCP) pathway where CELSR3 is directly involved. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor that prevents the breakdown of cAMP, thus indirectly activating PKA. PKA phosphorylation of Dsh/Dvl proteins can enhance the PCP pathway where CELSR3 functions. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to adrenergic receptors, which leads to the production of cAMP and thus activation of PKA. PKA phosphorylation of Dsh/Dvl proteins modulates the PCP pathway, in which CELSR3 plays a role. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterase enzymes, leading to an increase in cAMP levels. The resulting PKA activation and subsequent phosphorylation of Dsh/Dvl proteins can enhance the PCP pathway where CELSR3 functions. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, by binding to D1 receptors, increases cAMP levels and activates PKA. PKA phosphorylation of Dsh/Dvl proteins can enhance the PCP pathway where CELSR3 functions. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its H2 receptors, activates adenylyl cyclase, leading to increased cAMP levels. The resulting PKA activation and subsequent phosphorylation of Dsh/Dvl proteins can enhance the PCP pathway where CELSR3 functions. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
3-(2-Aminoethyl)-1H-indol-5-ol (Serotonin), by binding to its 5-HT4, 5-HT6, and 5-HT7 receptors, activates adenylyl cyclase and increases cAMP levels. The resulting PKA activation and subsequent phosphorylation of Dsh/Dvl proteins can enhance the PCP pathway where CELSR3 functions. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
L-Noradrenaline, by binding to its beta-adrenergic receptors, activates adenylyl cyclase and increases cAMP levels. The resulting PKA activation and subsequent phosphorylation of Dsh/Dvl proteins can enhance the PCP pathway where CELSR3 functions. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific phosphodiesterase inhibitor, which raises cAMP levels, leading to PKA activation. The subsequent phosphorylation of Dsh/Dvl proteins can enhance the PCP pathway where CELSR3 functions. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, by binding to beta-adrenergic receptors, activates adenylyl cyclase, which increases cAMP levels. The resulting PKA activation and subsequent phosphorylation of Dsh/Dvl proteins can enhance the PCP pathway where CELSR3 functions. | ||||||