CDT6 Inhibitors
CDT6 inhibitors are a class of chemical compounds that specifically target and inhibit the CDT6 (Cyclin-Dependent Toxin 6) protein, a member of the cyclin-dependent family of proteins involved in cell cycle regulation and signaling. CDT6 is thought to play a key role in controlling various stages of the cell cycle, particularly in the regulation of processes such as DNA replication, repair, and cellular division. CDT6 is involved in complex signaling networks that ensure cells progress through the different phases of the cell cycle in a controlled manner. By inhibiting CDT6, these compounds interfere with the normal functioning of the protein, leading to alterations in how cells manage critical processes such as growth and division.
The mechanism by which CDT6 inhibitors work typically involves binding to active sites or key domains of the CDT6 protein, preventing it from interacting with other proteins or cellular factors that are crucial for its function. This inhibition can disrupt the coordination of the cell cycle, influencing how cells respond to various regulatory signals and altering their ability to progress through different phases. CDT6 inhibitors are valuable tools for studying the molecular mechanisms underlying cell cycle control, as they help to isolate the role of CDT6 within the broader network of cyclin-dependent proteins. By using these inhibitors, researchers can gain insights into the intricate processes of cellular regulation and investigate how CDT6 contributes to maintaining the integrity of cellular division and growth. This class of inhibitors serves as a powerful resource for understanding the biological functions of CDT6 and its broader role in the regulation of cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may interact with histone deacetylases to enhance acetylation near the CDT6 gene locus, potentially leading to a condensed chromatin state and decreased transcriptional activity of the CDT6 gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could cause hypomethylation of the CDT6 gene promoter, possibly resulting in the suppression of its transcriptional initiation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may disrupt specific transcription factor binding to the promoter region of the CDT6 gene, leading to a decrease in CDT6 mRNA synthesis and subsequent protein expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could initiate the activation of sirtuin enzymes that deacetylate histones associated with the CDT6 gene, potentially leading to transcriptional repression and a reduction in CDT6 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could bind to retinoid acid receptors that interact with the CDT6 gene promoter, leading to altered transcription factor recruitment and a consequent decrease in CDT6 expression. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone may block mineralocorticoid receptors, leading to altered transcription of target genes and potentially causing a decrease in CDT6 mRNA and protein levels. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A may bind to GC-rich sequences in the DNA, preventing the binding of transcriptional machinery to the CDT6 gene and leading to diminished gene expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting mTOR complex 1, Rapamycin could downregulate protein synthesis pathways, which may include the translational machinery required for CDT6 protein production. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002, as a PI3K inhibitor, could lead to a reduction in AKT phosphorylation levels, potentially causing a downstream decrease in CDT6 gene expression through reduced transcriptional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 inhibits MEK1/2, which may lead to reduced ERK phosphorylation and activity, resulting in the downregulation of transcription factors that drive CDT6 gene expression. | ||||||