Cdt2 Inhibitors

Cdt2 inhibitors represent a group of compounds that indirectly interfere with the function of the Cdt2 protein. These inhibitors act through various mechanisms to disrupt the cellular processes in which Cdt2 is involved. For instance, they target the neddylation process that is crucial for the activation of Cullin-RING ligases, including the CRL4^Cdt2 complex. By inhibiting the NEDD8-activating enzyme, inhibitors effectively block the neddylation that is necessary for Cdt2 to function properly. Inhibitors influence a myriad of signaling pathways that indirectly affect Cdt2 function.

Cdt2 inhibitors may alter the synthesis and degradation balance of proteins, including those involved in the pathways Cdt2 regulates. Inhibitors exert their influence by modulating the cell cycle and gene expression, respectively. Inhibitors impact the cell's response to oxidative stress, which could influence the expression and function of proteins that interact with Cdt2 or are part of its regulatory network. In summary, Cdt2 inhibitors encompass a diverse array of chemical agents that share the common feature of indirectly impeding the function of the Cdt2 protein. These inhibitors work through a variety of mechanisms, including but not limited to, hindering the neddylation process, proteasome function, cell cycle regulation, gene expression modulation, and stress response pathways. These inhibitors have a distinct mode of action, yet they collectively contribute to the suppression of Cdt2 activity by affecting the protein's ability to regulate its substrates within the cell.