Cdk1/Cdk2 Activators
Cyclin-dependent kinases 1 and 2 (Cdk1/Cdk2) are key regulators of the cell cycle, playing pivotal roles in orchestrating cell division and proliferation. These serine/threonine kinases form complexes with regulatory cyclin proteins, which control their activity through the cell cycle phases. Cdk1, also known as Cdc2, predominantly regulates the G2/M transition, while Cdk2 is primarily involved in the G1/S transition. Together, Cdk1 and Cdk2 regulate critical events such as DNA replication, chromosome condensation, and mitotic spindle assembly, ensuring accurate segregation of genetic material and faithful cell division. Dysregulation of Cdk1/Cdk2 activity is associated with various pathological conditions, including cancer, where aberrant cell cycle progression contributes to uncontrolled proliferation and tumor growth.
The activation of Cdk1/Cdk2 is tightly regulated through multiple mechanisms to ensure precise temporal control over cell cycle progression. One primary mode of activation involves the binding of cyclin proteins, such as cyclin A, cyclin B, and cyclin E, to form active cyclin-Cdk complexes. The synthesis and degradation of cyclins are tightly regulated throughout the cell cycle, with distinct cyclins being expressed and degraded at specific phases to activate the corresponding Cdk partners. Additionally, phosphorylation events mediated by upstream kinases, such as cyclin-dependent kinase-activating kinases (CAKs), further modulate Cdk activity by promoting conformational changes and enhancing substrate specificity. Furthermore, Cdk inhibitors, such as the INK4 and Cip/Kip families, act as negative regulators by binding to and inhibiting Cdk-cyclin complexes, providing an additional layer of control over cell cycle progression. The intricate balance between activating and inhibitory signals governs the activity of Cdk1/Cdk2 complexes, ensuring proper cell cycle regulation and maintenance of genomic integrity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A increases acetylation of histones, leading to a more open chromatin structure. This change facilitates increased transcription of various genes, including those regulating cell cycle, potentially activating the expression and function of Cdks. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
This compound is a tyrosine kinase inhibitor that disrupts phosphorylation events critical for cell signaling. By inhibiting these kinases, Genistein can activate the transcription and activity of various cell cycle-related genes, including those encoding Cdks. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, binds to retinoic acid receptors and alters gene expression. It plays a crucial role in cell differentiation and can activate the expression of genes involved in the cell cycle, including those encoding Cdks. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide interferes with DNA replication by inhibiting the enzyme topoisomerase II, causing DNA damage. This damage leads to alterations in the expression of cell cycle regulators, including genes encoding Cdks, impacting cell cycle control. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, modulates cell signaling pathways and can influence the expression of numerous cell cycle-related proteins. It exerts its effects by altering transcription factor activity and signaling cascades that regulate the expression of Cdks. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, modulates signaling pathways involved in cell growth and survival. It can indirectly activate the expression of Cdks by modulating these pathways, impacting cell cycle regulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, Induces phase II detoxification enzymes and alters gene expression. This alteration includes activation of genes related to the cell cycle, potentially impacting Cdk expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound in turmeric, affects multiple cell signaling pathways. These pathways can influence the expression of various genes, including those encoding Cdks, thereby potentially activating Cdk-mediated cell cycle regulation. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
A synthetic nonsteroidal estrogen, Diethylstilbestrol can interfere with hormone-regulated pathways. This interference could lead to changes in the expression of genes, including those encoding Cdks, activating their function in cell cycle regulation. | ||||||