CD96 Activators
CD96 activators are chemical compounds that enhance the functional activity of CD96, a protein involved in T cell activation and signalling. These activators work by influencing specific cellular processes and signaling pathways that CD96 is directly involved in. Compounds such as A23187 (Calcimycin) and Ionomycin enhance CD96 activity by increasing intracellular calcium levels, which is necessary for T cell activation. Similarly, Forskolin and IBMX promote CD96 activity by enhancing cAMP levels, another key signal in T cell activation.
Additionally, several CD96 activators function by modulating protein kinase activity. Phorbol 12-myristate 13-acetate (PMA), Bryostatin 1 and Sanguinarine activate protein kinase C (PKC), which is known to phosphorylate and activate CD96. In contrast, H-89 and Staurosporine inhibit other protein kinases, thereby increasing the reliance on CD96 for T cell activation. Finally, compounds such as Okadaic Acid and ZAP-70 Inhibitor enhance CD96 activity by inhibiting protein phosphatases and key players in T cell receptor signaling respectively, thereby increasing the overall importance of CD96 in the T cell activation process.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a mobile ion carrier that forms complexes with divalent cations, especially calcium, and transports these ions through the cell membrane. Increased cytosolic calcium can lead to enhanced CD96 activity as it is involved in T cell activation which relies on calcium signalling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which is known to phosphorylate and activate CD96. By activating PKC, PMA can directly enhance CD96 activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Enhanced calcium signaling can lead to increased CD96 activity, as CD96 is involved in T cell activation which relies on calcium signalling. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 is a potent activator of protein kinase C (PKC), which is known to phosphorylate and activate CD96. By activating PKC, Bryostatin 1 can directly enhance CD96 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, which increases cyclic AMP (cAMP) levels. Elevated cAMP can enhance CD96 activity by promoting T cell activation, a process in which CD96 is directly involved. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that increases intracellular cAMP levels. Elevated cAMP promotes T cell activation, and thereby enhances CD96 activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased protein phosphorylation. Increased phosphorylation can enhance CD96 activity, as CD96 is known to be activated by phosphorylation. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Sanguinarium is a potent activator of protein kinase C (PKC), which is known to phosphorylate and activate CD96. By activating PKC, Sanguinarine can directly enhance CD96 activity. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressant that inhibits calcineurin, a phosphatase that dephosphorylates NFAT, a key transcription factor in T cell activation. Inhibition of calcineurin can increase reliance on CD96 for Tcell activation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC, that can indirectly enhance CD96 function by increasing the reliance on CD96 for T cell activation. | ||||||