CD66CE Inhibitors
CD66CE inhibitors are chemical compounds that target CD66CE, a subset of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family. CD66CE refers to the group of proteins within this family, specifically those involved in cellular adhesion, signaling, and immune regulation. CEACAMs, including CD66CE, are glycoproteins expressed on the surface of various cell types, particularly epithelial and immune cells. These proteins play a key role in intercellular interactions, modulating processes such as cell migration, cellular recognition, and immune responses. CD66CE proteins are also involved in homotypic and heterotypic cell adhesion, forming critical bridges in the communication between cells in the immune system and tissues. Inhibitors of CD66CE are designed to block the interactions these proteins facilitate, thereby altering the biological processes that depend on these adhesion and signaling functions.
The design and development of CD66CE inhibitors require a detailed understanding of the structural domains involved in CEACAM-mediated cell adhesion. These inhibitors can range from small molecules that block specific binding sites to peptides or antibodies that interfere with protein-protein interactions. The inhibitors are engineered to selectively bind to the key domains of CD66CE, preventing it from engaging with other proteins or receptors that mediate adhesion or signaling. Important considerations during the development process include achieving high specificity to avoid cross-reactivity with other CEACAM family members, as well as optimizing the binding affinity and stability of the inhibitors. By inhibiting CD66CE, these compounds allow researchers to explore the functional roles of CEACAMs in cellular adhesion, immune modulation, and tissue integrity, contributing to a broader understanding of the molecular mechanisms that govern cell-cell communication in diverse biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may downregulate CD66CE expression by inhibiting the transcription factor NF-κB, which in turn could lead to reduced transcription of the gene encoding CD66CE, thereby decreasing its presence in cell signaling pathways associated with proliferation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could decrease the expression of CD66CE by activating the sirtuin family of proteins, which are known to deacetylate histones and alter chromatin structure, thus leading to repression of gene expression including that of CD66CE. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane might reduce CD66CE levels by inhibiting histone deacetylase (HDAC) activity, promoting a chromatin structure that is less conducive to transcription and thereby lowering CD66CE gene expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin has the potential to decrease CD66CE expression by inhibiting the phosphorylation of signal transducers and activators of transcription (STAT) proteins, which are critical for the expression of certain genes involved in cell survival and proliferation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate might suppress the expression of CD66CE via inhibition of the PI3K/Akt signaling pathway, leading to a reduction in transcriptional activity of genes involved in cellular growth, including CD66CE. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could reduce CD66CE expression by binding to retinoic acid receptors, which then bind to retinoic acid response elements in the promoter regions of target genes, including potentially the CD66CE gene, repressing their transcription. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol can lead to the decreased expression of CD66CE by altering the metabolism of estrogen, which may subsequently reduce estrogen receptor signaling and downstream gene expression, including that of CD66CE. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein may inhibit the expression of CD66CE by functioning as a tyrosine kinase inhibitor, leading to the suppression of kinase-dependent signaling pathways that drive the expression of genes like CD66CE. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid could lead to the downregulation of CD66CE by protecting DNA from oxidative damage and promoting the expression of genes that encode for detoxifying enzymes, thereby influencing cell cycle regulation and reducing the expression of proliferation-related genes. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
3,3'-Diindolylmethane may reduce CD66CE expression by modifying the signaling pathways mediated by estrogen receptors, which can result in the suppression of downstream target genes involved in cell proliferation and adhesion. | ||||||