CD66CE Activators
CD66CE, also known as carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), is a glycosylated immunoglobulin superfamily member primarily recognized for its role in cell-cell adhesion. The protein is typically expressed on the surface of epithelial cells and has been studied extensively for its function in cellular communication and adhesion, playing a pivotal role in maintaining the integrity and architecture of epithelial layers. The expression of CD66CE is subject to regulation by a complex interplay of intracellular signaling pathways and extracellular cues, which can be modulated by various chemical compounds. Understanding the mechanisms that induce the expression of CD66CE is crucial for elucidating its function in normal cellular physiology.
Several chemical activators have the potential to upregulate the expression of CD66CE, each acting through distinct molecular mechanisms. Compounds such as retinoic acid and vitamin D3 are known for their abilities to bind to specific nuclear receptors, which in turn bind to DNA response elements in the promoter regions of target genes, including those coding for cell adhesion molecules like CD66CE. These interactions can lead to transcriptional activation and subsequent protein expression. Other chemicals, such as the short-chain fatty acid sodium butyrate, can alter epigenetic marks on histone proteins, effectively loosening chromatin structure and increasing gene accessibility for transcriptional machinery. Forskolin, known for its role in raising intracellular cAMP levels, activates downstream effectors like protein kinase A, resulting in the phosphorylation of transcription factors that can enhance the expression of CD66CE. In addition to these, certain polyphenolic compounds, such as EGCG found in green tea, have been observed to exert antioxidant properties that can trigger cellular defense mechanisms, including the activation of signaling pathways that lead to the upregulation of various genes. While the exact mechanisms by which these chemicals induce CD66CE expression may differ, they collectively underscore the intricate network of regulatory processes that control the expression of this important cell adhesion molecule.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can upregulate CD66CE expression through direct activation of retinoid receptors, leading to altered transcription of genes associated with cell differentiation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone might stimulate CD66CE expression by binding to glucocorticoid receptors, which can initiate transcriptional changes in immune cells, including upregulation of certain adhesion molecules. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol could potentially increase CD66CE expression by engaging estrogen receptors, which trigger a cascade of gene expression changes in responsive tissues. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol may induce CD66CE expression by activating its receptor, VDR, which then binds to vitamin D response elements in the genome, leading to transcriptional activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate can stimulate CD66CE expression by inhibiting histone deacetylases, thereby allowing transcription factors greater access to the CD66CE gene promoter regions. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin might increase CD66CE expression via activation of adenylyl cyclase, raising intracellular cAMP levels and activating protein kinase A (PKA), which can enhance transcription of target genes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA may stimulate CD66CE expression by mimicry of diacylglycerol, activating protein kinase C (PKC) and altering gene expression through downstream signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could upregulate CD66CE expression as a consequence of its role as an antioxidant, which can initiate protective gene expression responses including those of cell adhesion molecules. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO might induce CD66CE expression as part of its role in promoting differentiation in certain cell lines, which involves a complex network of gene expression changes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can stimulate CD66CE expression by inhibiting glycogen synthase kinase-3 (GSK-3), thereby activating Wnt signaling and promoting the transcription of Wnt target genes. | ||||||