PMA CAS: 16561-29-8
MF: C36H56O8
MW: 616.83

PMA (CAS 16561-29-8)

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PMA is rated 4.83 out of 5 by 6.
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Nomes alternativos: PMA is also known as Phorbol-12-Myristate-13-Acetate.
Aplicação PMA is a reversible and highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations.
Numero VAT: 16561-29-8
Privada: ≥95%
Peso Molecular: 616.83
Separar por Funcao: C36H56O8
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
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PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. PMA is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA′s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC. PMA activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. PMA has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells. PMA is also known as Phorbol-12-Myristate-13-Acetate, TPA, 12-O-Tetradecanoylphorbol-13-acetate, PKC Activator I, and tetradecanoic acid, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester.


Referencias

1. Castagna, M., et al. 1982. J. Biol. Chem. 257: 7847-7851. PMID: 7085651

2. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. U.S.A. 82: 2774-2778. PMID: 2859591

3. Saltis, J., et al. 1991. J. Biol. Chem. 266: 261-267. PMID: 1985898

4. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73: 2011-2015. PMID: 1474079

5. Oishi, K. and Yamaguchi, M. 1994. J. Cell. Biochem. 55: 168-172. PMID: 8089192

6. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. U.S.A. 92: 8443-8447. PMID: 7545303

7. Powell, D.J., et al. 2003. Mol. Cell. Biol. 23: 7794-7808. PMID: 14560023

8. Saraiva, L., et al. 2004. Eur. J. Pharmacol. 491: 101-110. PMID: 15140626

9. Shimura, C., et al. 2010. Am. J. Pathol. 176: 227-237. PMID: 20008150

Paginas :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month.
Estado físico :
Solid
envie :
Soluble in DMSO (25 mg/ml), 100%ethanol (25 mg/ml), acetone, ether, DMF, methanol, and chloroform. Insoluble in water, and aqueous buffers.
Manutencao :
Store at -20° C
Ponto de fusão :
50-70° C
Ponto de fervura :
~698.10° C at 760 mmHg (Predicted)
Densidade :
1.17 g/cm3 (Predicted)
Indice de produtos :
n20D 1.55 (Predicted)
Reatividade :
α24D +49, c = 1 in dioxane
Data ki :
PKC: Ki= 2.6 nM
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
RTECS :
QH4377000
PubChem CID :
Indice de produtos :
14: 7332
Numero de FAX :
MFCD00036736
Registro Beilstein :
2407201
SMILES :

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PMA (CAS 16561-29-8)  Citacoes dos Produtos

Visualizar com outras pessoas usaram PMA (CAS 16561-29-8). Clique em PubMed para ver .

Citações 1 para 10 de 87 total

PMID: # 33558623  Malek, N.|Michrowska, A.|Mazurkiewicz, E.|Mrówczyńska, E.|Mackiewicz, P.|Mazur, AJ.| et al. 2021. Sci Rep. 11: 3329.

PMID: # 34063504  Damato, M.|Cardon, T.|Wisztorski, M.|Fournier, I.|Pieragostino, D.|Cicalini, I.|Salzet, M.|Vergara, D.|Maffia, M.| et al. 2021. Int J Mol Sci. 22:

PMID: # 33622708  Chan, W.|Gottschalk, RA.|Yao, Y.|Pomerantz, JL.|Germain, RN.| et al. 2021. Immunohorizons. 5: 117-132.

PMID: # 33883175  Holthof, LC.|van der Schans, JJ.|Katsarou, A.|Poels, R.|Gelderloos, AT.|Drent, E.|van Hal-van Veen, SE.|Li, F.|Zweegman, S.|van de Donk, NWCJ.|Themeli, M.|Groen, RWJ.|Mutis, T.| et al. 2021. Clin Cancer Res.

PMID: # 32795666  Schuster, R.|Motola-Kalay, N.|Baranovski, BM.|Bar, L.|Tov, N.|Stein, M.|Lewis, EC.|Ayalon, M.|Sagiv, Y.| et al. 2020. Cell Immunol. 356: 104177.

PMID: # 33443102  De Luca, E.|Perrelli, A.|Swamy, H.|Nitti, M.|Passalacqua, M.|Furfaro, AL.|Salzano, AM.|Scaloni, A.|Glading, AJ.|Retta, SF.| et al. 2020. J Cell Sci.

PMID: # 33901996  Gomes Coutinho, AG.|Pinheiro, E.|Fernandez, R.| et al. 2020. J Physiol Pharmacol. 71:

PMID: # 31321035  Kwiatkowski, BA.|Burwick, NR.|Richard, RE.| et al. 2019. Biomark Res. 7: 13.

PMID: # 31145102  Halkias, J.|Rackaityte, E.|Hillman, SL.|Aran, D.|Mendoza, VF.|Marshall, LR.|MacKenzie, TC.|Burt, TD.| et al. 2019. J. Clin. Invest. 130:

PMID: # 31311871  Liang, D.|Wu, K.|Tei, R.|Bumpus, TW.|Ye, J.|Baskin, JM.| et al. 2019. Proc Natl Acad Sci U S A. 116: 15453-15462.

Citações 1 para 10 de 87 total
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