CCP3 Activators
CCP3 Activators are a diverse set of chemical compounds that influence various biochemical pathways, ultimately leading to the enhancement of CCP3's functional activity. Forskolin, through its action on adenylyl cyclase, increases cAMP levels and activates PKA, which may phosphorylate proteins in CCP3's signaling cascade, thereby enhancing its activity. Similarly, PMA activates PKC, which could phosphorylate and positively influence CCP3-related pathways. EGCG, by inhibiting certain kinases, may relieve negative regulation on CCP3, allowing for an increase in its activity. Ionomycin and A23187, as calcium ionophores, raise intracellular calcium levels and thus activate calcium-dependent enzymes that could enhance CCP3's signaling. S1P, through its receptor-mediated actions, may activate downstream effectors that lead to CCP3 activation.
Furthermore, inhibitors like LY294002 and U0126 target PI3K and MEK1/2, respectively, leading to a shift in cellular signaling that may favor CCP3 activation. SB203580, by inhibiting p38 MAP kinase, potentially allows for the activation of alternate pathways that could support CCP3's functions. Staurosporine, although a general kinase inhibitor, may indirectly enhance CCP3 activity by preferentially inhibiting kinases that negatively regulate CCP3. Anisomycin triggers the JNK stress-response pathway, which might indirectly enhance CCP3 activity. Okadaic acid, by inhibiting protein phosphatases like PP1 and PP2A, leads to an increase in the phosphorylation state of proteins within CCP3 signaling pathways, potentially amplifying CCP3's activity. Collectively, these CCP3 Activators exert their effects through intricate signaling networks, ensuring the enhancement of CCP3's functions without the need for direct binding or upregulation at the genetic level.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpene that activates the enzyme adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP levels can enhance CCP3 activity by activating protein kinase A (PKA), which may phosphorylate and activate downstream proteins involved in CCP3's functional pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diester of phorbol and a potent activator of protein kinase C (PKC). PKC activation can lead to the phosphorylation of target proteins that are part of CCP3's signaling cascade, resulting in the enhancement of CCP3's activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibitory activity. By inhibiting certain kinases, EGCG may reduce negative regulatory influences on CCP3, leading to its increased activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, thereby potentially modulating calcium-dependent protein kinases and phosphatases that can enhance CCP3 signaling pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that acts through G protein-coupled receptors to activate downstream signaling pathways, including those that could augment CCP3 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphatidylinositol 3-kinase (PI3K). Inhibition of PI3K can lead to altered downstream signaling that may enhance CCP3's functional role in the cell. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of mitogen-activated protein kinase kinases (MEK1/2). By inhibiting MEK1/2, U0126 may shift signaling dynamics in favor of pathways that enhance CCP3 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Inhibiting p38 can lead to the activation of alternative pathways that may support the enhancement of CCP3's activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, similar to ionomycin, and can activate calcium-dependent signaling pathways that may enhance CCP3 function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. Although it inhibits multiple kinases, it can selectively activate CCP3-related pathways by disinhibiting specific proteins that usually repress CCP3's activity. | ||||||