CCDC125 Activators
CCDC125 is a protein that is regulated through various post-translational modifications, including phosphorylation, which can significantly alter its functional activity. One way in which CCDC125 is activated is through the elevation of intracellular cyclic AMP levels. Compounds that enhance adenylyl cyclase activity or inhibit phosphodiesterases lead to an accumulation of cAMP within the cell, resulting in the activation of protein kinase A (PKA). PKA, in turn, phosphorylates CCDC125, thus modulating its activity. Additionally, certain agonists that bind to G protein-coupled receptors can also increase cAMP levels, further contributing to PKA-mediated activation of CCDC125. This mechanism of action demonstrates the importance of the cAMP-PKA signaling axis in the regulation of CCDC125 activity.
Moreover, CCDC125 activity is influenced by other cellular kinases that are activated by various stimuli. For instance, kinase activators that target protein kinase C (PKC) or the Jun N-terminal kinase (JNK) pathway can phosphorylate CCDC125, thereby affecting its functional state. Calcium influx within the cell can activate calcium-dependent kinases, which may also result in the phosphorylation and subsequent activation of CCDC125. Additionally, the inhibition of protein phosphatases creates a cellular environment conducive to the sustained phosphorylation of proteins like CCDC125, thereby maintaining them in an active state.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP activates PKA, which can phosphorylate CCDC125, resulting in increased functional activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that enhances cAMP production through G protein-coupled receptor signaling, leading to PKA activation which can phosphorylate and increase the activity of CCDC125. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective phosphodiesterase inhibitor that prevents cAMP degradation, thereby sustaining PKA activation and potential phosphorylation of CCDC125, enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activator of protein kinase C (PKC) that can modulate phosphorylation states of proteins within the cell. PKC-mediated phosphorylation may result in the functional activation of CCDC125. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent protein kinases which may phosphorylate and activate CCDC125. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Activator of G protein-coupled receptors which can lead to the activation of downstream kinases that could phosphorylate and increase the activity of CCDC125. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP levels and sustained activation of PKA, which in turn may phosphorylate and activate CCDC125. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
An activator of the stress-activated protein kinases such as JNK, which could phosphorylate substrates, including CCDC125, leading to its activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
A serine/threonine phosphatase inhibitor, which can prevent the dephosphorylation of proteins, potentially leading to a sustained phosphorylated and active state of CCDC125. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of cellular proteins, which could enhance the phosphorylation state and activity of CCDC125. | ||||||