CCDC109B Activators
CCDC109B activators include compounds that can increase cytosolic calcium concentration or disrupt normal calcium transport, thereby indirectly enhancing CCDC109B activity. A23187 is a mobile ion carrier that forms complexes with divalent cations, especially calcium, and transports these ions through the cell membrane.
The second group of CCDC109B activators includes Cyclopiazonic Acid, Ryanodine, BAPTA-AM, Nigericin, FCCP, Probenecid, Bay K 8644, and Thapsigargin. These compounds have various mechanisms of action that can either increase cytosolic calcium concentration or disrupt mitochondrial membrane potential, thereby enhancing CCDC109B activity. Cyclopiazonic Acid and Thapsigargin are inhibitors of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to an increase in cytosolic calcium concentration. Ryanodine and Bay K 8644 modulate intracellular calcium release or activate calcium channels, respectively, to increase cytosolic calciumconcentration. BAPTA-AM and Probenecid are compounds that can increase cytosolic calcium concentration via different mechanisms. Nigericin and FCCP are compounds that disrupt mitochondrial membrane potential, thereby enhancing CCDC109B activity by increasing the demand for mitochondrial calcium uptake.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a mobile ion carrier that forms complexes with divalent cations (especially calcium) and transports these ions through the cell membrane. As CCDC109B is involved in mitochondrial calcium uptake, increased cytosolic calcium can lead to enhanced CCDC109B activity. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid is an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA). Inhibition of SERCA can lead to an increase in cytosolic calcium concentration, indirectly enhancing CCDC109B activity. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine is a plant alkaloid that modulates intracellular calcium release. It can increase cytosolic calcium, which can then be taken up by the mitochondria via CCDC109B, indirectly enhancing its activity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeant calcium chelator that can lead to an increase in cytosolic calcium concentration, thereby indirectly enhancing CCDC109B activity. | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $46.00 $112.00 $240.00 $7079.00 $27417.00 | 9 | |
Nigericin acts as a H+/K+ antiporter and can disrupt mitochondrial membrane potential. This disruption can enhance CCDC109B activity by increasing the demand for mitochondrial calcium uptake. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
FCCP is an uncoupler of oxidative phosphorylation that disrupts mitochondrial membrane potential. This disruption can increase the demand for mitochondrial calcium uptake, thereby enhancing CCDC109B activity. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Probenecid is a weak organic acid that can increase cytosolic calcium concentration, which can then be taken up by the mitochondria via CCDC109B, indirectly enhancing its activity. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K 8644 is an L-type calcium channel activator. By activating these channels, it increases cytosolic calcium concentration, indirectly enhancing CCDC109B activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) that can increase cytosolic calcium concentration, thereby indirectly enhancing CCDC109B activity. | ||||||