Molecular structure of Nigericin sodium salt, CAS Number: 28643-80-3
Nigericin sodium salt (CAS 28643-80-3)
See product citations (9)
Alternate Names:
Antibiotic K 178
Application:
Nigericin sodium salt is a polyether antibioitc K+ and Na+ ionophore
CAS Number:
28643-80-3
Purity:
98%
Molecular Weight:
746.94
Molecular Formula:
C40H67O11•Na
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nigericin sodium salt, a polyether antibiotic K+ and Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential and stimulates ATPase activity leading to rapid intracellular acidification resulting in apoptosis. Nigericin•Na has shown a role for inducing caspase-1-independent necrotic cell death. Nigericin•Na has also been found to increase membrane potential accelerating the rate of superoxide generation approaching the rate obtained by antimycin. Nigericin•Na is an activator of Cryopyrin.
Nigericin sodium salt (CAS 28643-80-3) References
- Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. | Hentze, H., et al. 2003. Cell Death Differ. 10: 956-68. PMID: 12934070
- Nigericin-stimulated ATPase activity in microsomal vesicles of tobacco callus. | Sze, H. 1980. Proc Natl Acad Sci U S A. 77: 5904-8. PMID: 16592894
- Membrane potential greatly enhances superoxide generation by the cytochrome bc1 complex reconstituted into phospholipid vesicles. | Rottenberg, H., et al. 2009. J Biol Chem. 284: 19203-10. PMID: 19478336
- Validation of a liquid chromatography-electrospray ionization tandem mass spectrometric method to determine six polyether ionophores in raw, UHT, pasteurized and powdered milk. | Pereira, MU., et al. 2016. Food Chem. 196: 130-7. PMID: 26593474
- Nigericin and grisorixin methyl ester from the Algerian soil-living Streptomyces youssoufiensis SF10 strain: a computational study on their epimeric structures and evaluation of glioblastoma stem cells growth inhibition. | Leulmi, N., et al. 2019. Nat Prod Res. 33: 266-273. PMID: 29513090
- NLRP3 augmented resistance to gemcitabine in triple-negative breast cancer cells via EMT/IL-1β/Wnt/β-catenin signaling pathway. | Zheng, Q., et al. 2020. Biosci Rep. 40: PMID: 32578856
- CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway. | Cao, X., et al. 2021. Inflammation. 44: 1023-1034. PMID: 33405023
- Real-time in vitro monitoring of the subcellular toxicity of inorganic Hg and methylmercury in zebrafish cells. | Yuan, L., et al. 2021. Aquat Toxicol. 236: 105859. PMID: 34004410
- Proanthocyanidins attenuate the high glucose-induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome. | Li, H., et al. 2021. J Biochem Mol Toxicol. 35: e22845. PMID: 34338401
- Electroacupuncture Stimulation Regulates Adipose Lipolysis via Catecholamine Signaling Mediated by NLRP3 Suppression in Obese Rats. | Lu, M., et al. 2021. Front Endocrinol (Lausanne). 12: 773127. PMID: 35046893
- The identity of the antibiotics nigericin, polyetherin A and X-464. | Stempel, A., et al. 1969. J Antibiot (Tokyo). 22: 384-5. PMID: 5345680
- Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria. | Vercesi, AE., et al. 1993. J Biol Chem. 268: 8564-8. PMID: 8473301
- Intracellular acidification induces apoptosis by stimulating ICE-like protease activity. | Furlong, IJ., et al. 1997. J Cell Sci. 110 (Pt 5): 653-61. PMID: 9092947
Inhibitor of:
9330182L06Rik, ATP6V0E1, ATP9B, Fucokinase, Mot1, and NDUFB3.Activator of:
γ-SNAP, ADP ribosylation factor (ARF), AIM2, ATP10C, ATP6E1, ATP6F, ATP6L, BIG1, CARD 8, caspase-1, CCDC109B, Cryopyrin, cyclin M1, Derlin-1, EG435376, ERGIC-2, FLJ13611, gasdermin, gasdermin A2, gasdermin A3, GILT, GSDML, Influenza A ns1, JAGN1, KDEL receptor 3, MARCH5, MASP-2, MLZE, NAIP2, NALP1, NALP2, NALP9, NCKX5, NEEP21, Nup93, P2X7, Plb2, Rab11-FIP5, RIP3, S2P, SCRN3, SEC23B, SERAC1, Slc16a5, SLC25A3, SLC25A45, TMEM168, TMEM229A, TMEM9, V-ATPase C1, V-ATPase G2, VMA21, VPS26, VPS26B, and VPS28.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nigericin sodium salt, 1 mg | sc-201518A | 1 mg | $46.00 | |||
Nigericin sodium salt, 5 mg | sc-201518 | 5 mg | $112.00 | |||
Nigericin sodium salt, 25 mg | sc-201518B | 25 mg | $240.00 | |||
Nigericin sodium salt, 1 g | sc-201518C | 1 g | $7079.00 | |||
Nigericin sodium salt, 5 g | sc-201518D | 5 g | $27417.00 |