CCDC109A Activators
Chemicals that function as CCDC109A activators do not interact with the protein directly but exert their effects through modulation of cellular calcium dynamics. These compounds induce an increase in intracellular calcium concentration, either by promoting calcium influx from the extracellular space, by mobilizing internal calcium stores from organelles such as the endoplasmic reticulum, or by modulating enzyme activities that influence calcium signaling pathways.
Compounds like Isoproterenol and Forskolin increase cytosolic cAMP, leading to PKA activation. PKA, in turn, phosphorylates downstream targets that enhance calcium influx or release from internal stores, indirectly facilitating CCDC109A activity by making more calcium available for mitochondrial uptake. A-23187 and Ionomycin act as ionophores to elevate intracellular calcium levels, promoting mitochondrial calcium uniporter activity and indirectly enhancing CCDC109A function. Histamine and ATP activate G protein-coupled receptors or purinergic receptors respectively, leading to increased cytosolic calcium via second messenger systems, again resulting in the activation of CCDC109A by facilitating mitochondrial calcium uptake. This elevation of cytosolic calcium is crucial for CCDC109A's role in mitochondrial calcium uptake, as the protein responds to calcium signals to regulate the mitochondrial calcium uniporter complex activity. Thus, compounds that effectively raise cytosolic calcium levels, whether by inducing calcium influx or release from intracellular stores, serve as indirect activators of CCDC109A.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that raises cytosolic cAMP levels, leading to PKA activation. PKA can phosphorylate proteins that regulate calcium channels, increasing cytosolic calcium levels, thereby indirectly enhancing CCDC109A activity as more calcium is available for uptake into the mitochondria. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
BAY K 8644 is an L-type calcium channel agonist that increases calcium influx, thus raising intracellular calcium levels. Elevated cytosolic calcium can activate CCDC109A indirectly by promoting the opening of the mitochondrial calcium uniporter and increasing calcium uptake into the mitochondria. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, increasing cAMP levels and activating PKA. PKA can phosphorylate and modulate proteins involved in calcium homeostasis, indirectly upregulating CCDC109A activity by increasing mitochondrial calcium uptake. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Phosphodiesterase (PDE) inhibitors like IBMX prevent the degradation of cAMP, leading to PKA activation. PKA phosphorylates various proteins that modulate calcium levels, thereby indirectly enhancing CCDC109A activity by promoting calcium entry into mitochondria. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine induces calcium release from the endoplasmic reticulum by antagonizing ryanodine receptors, thereby raising intracellular calcium levels and potentially increasing CCDC109A activity by enhancing mitochondrial calcium uptake. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A-23187 is an ionophore that increases intracellular calcium by transporting calcium across cellular membranes. Increased cytosolic calcium concentration can indirectly activate CCDC109A by promoting mitochondrial calcium entry. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Nicotinic acid, or niacin, can modulate calcium signaling through its action on G protein-coupled receptors. Elevated cytosolic calcium levels due to this modulation can indirectly promote CCDC109A activity by enhancing mitochondrial calcium uptake. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can raise intracellular calcium levels through its action on H1 receptors, leading to phospholipase C activation and IP3 production. Increased IP3 stimulates calcium release from the ER, indirectly enhancing CCDC109A activity by increasing mitochondrial calcium uptake. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP acts on purinergic receptors to mobilize intracellular calcium stores, indirectly enhancing CCDC109A activity by increasing the amount of calcium available for mitochondrial uptake. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to a rise in cytosolic calcium levels due to inhibition of calcium reuptake into the ER. This elevation of cytosolic calcium can indirectly activate CCDC109A by promoting calcium influx into the mitochondria. | ||||||