CCDC100 Activators
CCDC100 Activators encompass a range of chemical compounds that, despite not directly interacting with CCDC100, can elicit changes in cellular signaling pathways that result in the enhancement of CCDC100's functional activity. For instance, Forskolin and 8-Bromo-cAMP elevate intracellular cAMP levels, leading to Protein Kinase A (PKA) activation, which can phosphorylate substrates within CCDC100's signaling network, potentially enhancing its activity. Similarly, the use of ionophores like Ionomycin and A23187 results in increased intracellular calcium levels, activating calcium-dependent pathways that could indirectly influence the activity of CCDC100. Phorbol 12-myristate 13-acetate (PMA) and Sphingosine-1-phosphate activate protein kinase C (PKC) and G protein-coupled receptors, respectively, both of which have the potential to modulate downstream pathways that enhance CCDC100 activity.
Additionally, the manipulation of kinase signaling through various inhibitors and activators can indirectly augment the activity of CCDC100. LY294002 and Epigallocatechin gallate (EGCG), while primarily known as inhibitors of PI3K and various kinases respectively,can lead to compensatory signaling mechanisms that may positively influence CCDC100-related pathways. Inhibition of MAPK signaling using SB203580 and U0126 might also create a shift in cellular signaling that favors the activation of CCDC100. Okadaic acid's inhibition of phosphatases alters phosphorylation patterns, potentially leading to an upregulation of CCDC100 activity. Lastly, Thapsigargin, by increasing cytosolic calcium, can activate calcium-dependent proteins and pathways, adding another level of indirect activation of CCDC100. Collectively, these compounds act through distinct but interconnected pathways that converge to enhance the functional activity of CCDC100 without directly binding to or modifying the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP promotes PKA activation, which can phosphorylate other proteins that may indirectly enhance the functional activity of CCDC100 through downstream effects on its associated signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent PKC activator. By activating PKC, it can modulate phosphorylation states of proteins within the pathways CCDC100 is involved, thus potentially increasing CCDC100 activity indirectly. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. This elevation in calcium can activate calcium-dependent signaling cascades that may indirectly influence CCDC100 activity through secondary messengers or calcium-binding proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that alters PI3K/Akt signaling. Although it is an inhibitor, by affecting this pathway, it may cause compensatory effects that could enhance the functional pathways related to CCDC100. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. By inhibiting p38, it may shift cellular signaling dynamics, potentially enhancing pathways that positively regulate CCDC100 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which could lead to alterations in ERK pathway signaling. This can result in the modulation of pathways that indirectly increase the functional activity of CCDC100, by changing the phosphorylation patterns of proteins within the same network. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is involved in sphingolipid signaling and can activate G protein-coupled receptors, potentially influencing signaling cascades that indirectly modulate CCDC100 activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. It activates PKA and can induce changes in the phosphorylation state of proteins, potentially enhancing CCDC100's functional engagement in its signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can act as a kinase inhibitor. By inhibiting certain kinases, it might remove negative regulation on proteins that are part of CCDC100's pathways, indirectly enhancing CCDC100 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that raises intracellular calcium levels, potentially activating signaling pathways that could indirectly impact the functional activity of CCDC100. | ||||||