Date published: 2025-9-11

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CCDC100 Activators

CCDC100 Activators encompass a range of chemical compounds that, despite not directly interacting with CCDC100, can elicit changes in cellular signaling pathways that result in the enhancement of CCDC100's functional activity. For instance, Forskolin and 8-Bromo-cAMP elevate intracellular cAMP levels, leading to Protein Kinase A (PKA) activation, which can phosphorylate substrates within CCDC100's signaling network, potentially enhancing its activity. Similarly, the use of ionophores like Ionomycin and A23187 results in increased intracellular calcium levels, activating calcium-dependent pathways that could indirectly influence the activity of CCDC100. Phorbol 12-myristate 13-acetate (PMA) and Sphingosine-1-phosphate activate protein kinase C (PKC) and G protein-coupled receptors, respectively, both of which have the potential to modulate downstream pathways that enhance CCDC100 activity.

Additionally, the manipulation of kinase signaling through various inhibitors and activators can indirectly augment the activity of CCDC100. LY294002 and Epigallocatechin gallate (EGCG), while primarily known as inhibitors of PI3K and various kinases respectively,can lead to compensatory signaling mechanisms that may positively influence CCDC100-related pathways. Inhibition of MAPK signaling using SB203580 and U0126 might also create a shift in cellular signaling that favors the activation of CCDC100. Okadaic acid's inhibition of phosphatases alters phosphorylation patterns, potentially leading to an upregulation of CCDC100 activity. Lastly, Thapsigargin, by increasing cytosolic calcium, can activate calcium-dependent proteins and pathways, adding another level of indirect activation of CCDC100. Collectively, these compounds act through distinct but interconnected pathways that converge to enhance the functional activity of CCDC100 without directly binding to or modifying the protein itself.

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Items 11 to 12 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$285.00
$520.00
$1300.00
78
(4)

Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it can change the phosphorylation dynamics within cells, potentially leading to an enhancement of CCDC100-related signaling pathways.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels. This disruption in calcium homeostasis may activate calcium-dependent proteins and signaling pathways, indirectly enhancing CCDC100 activity.