Date published: 2025-9-5

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CBP Tag Inhibitors

CBP Tag Inhibitors comprise a range of compounds that indirectly inhibit the functional dynamics of CBP, a transcriptional coactivator involved in gene expression regulation and chromatin remodeling. These inhibitors operate through diverse mechanisms, influencing pathways and processes crucial for CBP's activation and function. They do not directly target the CBP Tag but affect the cellular environment or signaling cascades that indirectly modulate CBP's role in transcriptional coactivation. Chemicals such as Indirubin-3'-monoxime, Kenpaullone, and K-252a target kinases like CDKs and GSK-3, which are integral to various signaling pathways that ultimately influence transcription regulation, potentially impacting CBP's activity. Compounds like C646, Garcinol, and Anacardic Acid specifically inhibit CBP/p300 histone acetyltransferase (HAT) activity. This inhibition leads to reduced histone acetylation, a key process in chromatin remodeling that facilitates transcriptional activation. By inhibiting HAT activity, these compounds can decrease the transcriptional coactivation capability of CBP.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Indirubin-3′-monoxime

160807-49-8sc-202660
sc-202660A
sc-202660B
1 mg
5 mg
50 mg
$77.00
$315.00
$658.00
1
(1)

Inhibits cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3), potentially impacting transcriptional regulation pathways involving CBP.

C646

328968-36-1sc-364452
sc-364452A
10 mg
50 mg
$260.00
$925.00
5
(1)

Specific inhibitor of CBP/p300 HAT (histone acetyltransferase) activity, leading to reduced histone acetylation and potentially decreasing CBP-mediated transcriptional activation.

Garcinol

78824-30-3sc-200891
sc-200891A
10 mg
50 mg
$136.00
$492.00
13
(1)

Inhibitor of p300 and CBP HAT activity, potentially reducing transcriptional coactivation by CBP.

Anacardic Acid

16611-84-0sc-202463
sc-202463A
5 mg
25 mg
$100.00
$200.00
13
(1)

Inhibits p300 and CBP HAT activity, which may lead to decreased histone acetylation and reduced CBP-mediated transcriptional activation.

K-252a

99533-80-9sc-200517
sc-200517B
sc-200517A
100 µg
500 µg
1 mg
$126.00
$210.00
$488.00
19
(2)

Inhibitor of protein kinase C (PKC), which may indirectly affect CBP function by altering signaling pathways involved in transcription regulation.

Kenpaullone

142273-20-9sc-200643
sc-200643A
sc-200643B
sc-200643C
1 mg
5 mg
10 mg
25 mg
$60.00
$150.00
$226.00
$495.00
1
(1)

Inhibits GSK-3β and CDKs, potentially impacting pathways that indirectly influence CBP activity in gene transcription.

RGFP966

1357389-11-7sc-507300
5 mg
$115.00
(0)

Selective inhibitor of HDAC3 (histone deacetylase 3), potentially impacting chromatin remodeling and CBP-mediated transcription.

I-CBP112

1640282-31-0sc-507494
25 mg
$400.00
(0)

Direct inhibitor of the interaction between CBP and β-catenin, potentially affecting Wnt signaling-related transcription mediated by CBP.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Influences various signaling pathways and can impact transcription factors and coactivators including CBP.

Sirtinol

410536-97-9sc-205976
sc-205976A
1 mg
5 mg
$37.00
$111.00
14
(1)

Inhibitor of SIRT1 and SIRT2, NAD+-dependent histone deacetylases, potentially affecting chromatin remodeling and CBP-mediated transcription.