caveolin-3 Activators
Common caveolin-3 Activators include, but are not limited to Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) CAS 6217-54-5, Resveratrol CAS 501-36-0, Simvastatin CAS 79902-63-9, Methyl-β-cyclodextrin CAS 128446-36-6 and Pioglitazone hydrochloride CAS 112529-15-4.
Caveolin-3 activators are compounds or molecules that influence the activity of caveolin-3, a critical protein involved in the formation and maintenance of caveolae, small invaginations of the plasma membrane in various cell types. Caveolin-3 belongs to a family of proteins known as caveolins, which also includes caveolin-1 and caveolin-2. These proteins are primarily found in lipid rafts, specialized microdomains of the plasma membrane that are rich in cholesterol and glycosphingolipids. Caveolae play crucial roles in various cellular processes, including signal transduction, membrane trafficking, and lipid homeostasis. Caveolin-3, in particular, is predominantly expressed in muscle cells, both skeletal and cardiac, where it contributes to the structural integrity and proper functioning of caveolae in these cells.
Caveolin-3 activators are substances that modulate the function of caveolin-3, often by promoting its interaction with other proteins or by regulating its localization within the cell. These activators can influence the formation and stability of caveolae, affecting cellular processes that rely on these membrane structures. Understanding caveolin-3 activation is essential for elucidating its role in muscle cells and its impact on various physiological processes. Research in this field aims to uncover the specific mechanisms and pathways through which caveolin-3 activators exert their effects, shedding light on the intricate regulation of caveolae and their significance in cellular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
DHA, an omega-3 fatty acid, might influence caveolin-3 expression and caveolae formation, affecting membrane fluidity and signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to upregulate caveolin-3 expression, potentially through its antioxidant and anti-inflammatory properties. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Statins, like simvastatin, can influence caveolin-3 expression, possibly as part of their effects on cholesterol metabolism and caveolae formation. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
By extracting cholesterol from the membrane, MβCD can influence caveolae structure and potentially caveolin-3 expression. | ||||||
Pioglitazone hydrochloride | 112529-15-4 | sc-204848 sc-204848A | 100 mg 500 mg | $63.00 $213.00 | 19 | |
As a PPARγ agonist, pioglitazone might influence caveolin-3 expression as part of its broader effects on lipid metabolism and cellular signaling. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can affect caveolin-3 localization and expression, potentially as part of its effects on glucose uptake and muscle cell signaling. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine has been shown to influence caveolae structure and caveolin-3 expression, possibly through its effects on calcium signaling in muscle cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA can modulate the expression of various genes, potentially including caveolin-3, through its action on retinoic acid receptors. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol might influence caveolin-3 expression, potentially as part of its broader effects on muscle cell physiology and signaling. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
As a calcium channel blocker, nifedipine might influence caveolin-3 expression and function, especially in the context of muscle cell contraction and signaling. | ||||||