CatSperδ Activators
CatSperδ activators belong to a niche category of chemical agents that specifically target the CatSperδ protein, an essential component of the CatSper (Cation channels of sperm) complex. The CatSper complex itself is a heterotetrameric assembly of ion channels predominantly expressed in the sperm cells of many animals, including humans. These channels are known to be highly selective for calcium ions and are integral to the physiological process of sperm motility, which is critical for the proper functioning of male gametes. The δ subunit of CatSper, while not forming the ion-conducting pore itself, is crucial for the proper assembly and function of the channel complex. Activators of CatSperδ interact with this subunit, influencing the activity of the CatSper channel, subsequently affecting calcium influx into sperm cells.
The chemical nature of CatSperδ activators is diverse, with various molecules showing the ability to enhance the function of the CatSper complex. The specificity of CatSperδ activators means that they interact selectively with the δ subunit, modulating the activity of the CatSper channels in a way that alters the intracellular calcium levels within sperm cells. This modulation is achieved through direct or indirect mechanisms that can lead to changes in the biophysical properties of the channel, such as its activation kinetics, voltage dependence, or the duration of channel opening. The precise molecular interactions and binding sites of these activators on the δ subunit are a subject of ongoing research.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone is known to activate the CatSper channel, causing a rise in intracellular calcium, which can potentially activate CatSperδ. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
Niflumic acid can affect chloride channels in sperm and indirectly modulate calcium dynamics, potentially influencing CatSperδ activity. | ||||||
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $37.00 $1132.00 $120.00 | 3 | |
4-AP, a potassium channel blocker, may modify membrane potential in sperm, affecting CatSper channel activation and thus, potentially, CatSperδ. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin can activate TRPV1 channels in some cells, altering calcium dynamics, which might indirectly influence CatSperδ. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K8644 is an L-type calcium channel activator. By modulating calcium influx, it can indirectly influence CatSperδ activity. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB affects IP3 receptors and TRP channels, altering calcium dynamics in cells. This modulation may influence CatSperδ activity indirectly. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 inhibits receptor-mediated calcium entry. This altered calcium signaling can indirectly influence CatSperδ. | ||||||
CRAC Channel Inhibitor, BTP2 | 223499-30-7 | sc-221441 | 5 mg | $185.00 | 9 | |
BTP2 inhibits CRAC channels, affecting calcium dynamics. This could potentially influence the activity of CatSperδ indirectly. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine modulates ryanodine receptors, which control calcium release from internal stores, potentially affecting CatSperδ activity indirectly. | ||||||