CatSperδ Antibody (A-7): sc-393749
- CatSperδ Antibody (A-7) is a mouse monoclonal IgG2a κ CatSperδ antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 544-575 within an extracellular domain of CatSperδ of human origin
- CatSper delta Antibody (A-7) is recommended for detection of CatSperδ of human origin by WB, IP, IF and ELISA
- Anti-CatSper delta Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CatSperδ Antibody (A-7) for WB applications. These reagents are now offered in bundles with CatSperδ Antibody (A-7) (see ordering information below).
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CatSperδ Antibody (A-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects CatSperδ protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CatSperδ antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CatSperδ protein, a crucial component of the CatSper family, plays a significant role in sperm motility and fertilization by facilitating calcium influx in sperm cells. Located in the principal piece of the sperm tail, CatSperδ is a single-pass type I membrane protein composed of 798 amino acids and exists in two alternatively spliced isoforms, which are encoded by a gene located on human chromosome 19. CatSperδ′s unique structure, characterized by a single, six-transmembrane-spanning segment and a voltage-dependent calcium channel four-repeat structure, is essential for function as this allows for the formation of an alkalinization-activated calcium-selective channel. This channel is vital for proper sperm motility, and any mutations in genes encoding CatSper proteins can lead to male infertility, highlighting CatSperδ′s importance in reproductive health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CatSperδ Antibody (A-7) References:
- All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. | Qi, H., et al. 2007. Proc Natl Acad Sci U S A. 104: 1219-23. PMID: 17227845
- Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse. | Jin, J., et al. 2007. Biol Reprod. 77: 37-44. PMID: 17344468
- Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility. | Li, HG., et al. 2007. Mol Hum Reprod. 13: 299-306. PMID: 17347248
- CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation. | Xia, J., et al. 2007. Biol Reprod. 77: 551-9. PMID: 17554080
- Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum. | Suarez, SS., et al. 2007. Soc Reprod Fertil Suppl. 65: 331-4. PMID: 17644973
- A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. | Wang, H., et al. 2009. Biol Reprod. 81: 539-44. PMID: 19516020
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CatSperδ Antibody (A-7) | sc-393749 | 200 µg/ml | $316.00 | |||
CatSperδ Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-530567 | 200 µg Ab; 10 µg BP | $354.00 | |||
CatSperδ Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-524073 | 200 µg Ab, 40 µg BP | $354.00 | |||
CatSperδ Antibody (A-7): m-IgG2a BP-HRP Bundle | sc-547522 | 200 µg Ab; 10 µg BP | $354.00 | |||
CatSperδ Antibody (A-7) AC | sc-393749 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CatSperδ Antibody (A-7) HRP | sc-393749 HRP | 200 µg/ml | $316.00 | |||
CatSperδ Antibody (A-7) FITC | sc-393749 FITC | 200 µg/ml | $330.00 | |||
CatSperδ Antibody (A-7) PE | sc-393749 PE | 200 µg/ml | $343.00 | |||
CatSperδ Antibody (A-7) Alexa Fluor® 488 | sc-393749 AF488 | 200 µg/ml | $357.00 | |||
CatSperδ Antibody (A-7) Alexa Fluor® 546 | sc-393749 AF546 | 200 µg/ml | $357.00 | |||
CatSperδ Antibody (A-7) Alexa Fluor® 594 | sc-393749 AF594 | 200 µg/ml | $357.00 | |||
CatSperδ Antibody (A-7) Alexa Fluor® 647 | sc-393749 AF647 | 200 µg/ml | $357.00 | |||
CatSperδ Antibody (A-7) Alexa Fluor® 680 | sc-393749 AF680 | 200 µg/ml | $357.00 | |||
CatSperδ Antibody (A-7) Alexa Fluor® 790 | sc-393749 AF790 | 200 µg/ml | $357.00 | |||
CatSperδ (A-7) Neutralizing Peptide | sc-393749 P | 100 µg/0.5 ml | $68.00 |