CAT56 Activators
The first category of CAT56 activators is explicitly designed to modulate cAMP levels and PKA activity. Chemicals like Forskolin and Sp-8-Br-cAMPS act by directly increasing cAMP levels. Forskolin directly stimulates adenylate cyclase to produce cAMP, leading to subsequent PKA activation. PKA, when activated, directly phosphorylates CAT56, switching it to an active form. Sp-8-Br-cAMPS, a membrane-permeable analog of cAMP, directly targets PKA for activation without the need for adenylate cyclase, also leading to CAT56 phosphorylation and activation.
The second category focuses on altering calcium-dependent cellular processes to activate CAT56 directly. A23187, a calcium ionophore, allows Ca2+ to flow into the cell, causing an immediate increase in intracellular calcium levels. This surge activates calcium-dependent kinases that directly phosphorylate CAT56. Chelerythrine Chloride and PDBu act as direct activators of PKC. Both chemicals bind to the catalytic site of PKC, thereby phosphorylating and directly activating CAT56. This class of compounds serves to alter cellular biochemistry with the sole purpose of CAT56 activation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Directly activates adenylate cyclase, increasing cAMP levels, leading to PKA activation, which directly phosphorylates CAT56. | ||||||
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $119.00 $453.00 | 1 | |
Diacylglycerol analog that directly activates PKC, which in turn directly phosphorylates and activates CAT56. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore that directly increases intracellular Ca2+ levels, causing activation of calcium-dependent kinases that phosphorylate CAT56. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
Direct PKC activator that phosphorylates and activates CAT56 directly. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
CaMKII inhibitor that in its inactive form directly stabilizes the active form of CaMKII, which phosphorylates CAT56. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Inhibits cAMP phosphodiesterase, directly raising cAMP levels to activate PKA, which phosphorylates CAT56. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Directly activates PKC by binding at the catalytic site, leading to phosphorylation and activation of CAT56. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Directly inhibits PP2A and PP1, blocking dephosphorylation, thus stabilizing the phosphorylated (active) form of CAT56. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
cAMP-specific phosphodiesterase inhibitor, directly elevates cAMP levels, leading to PKA activation that phosphorylates CAT56. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Activates the JNK pathway, which directly phosphorylates and activates CAT56. | ||||||