CARD 8 Inhibitors
Chemical inhibitors of CARD 8 include a range of compounds that target the NF-kB signaling pathway, which is upstream of CARD 8's role in inflammasome assembly and activation. Parthenolide acts to impede the inflammatory cascade by blocking the IκB kinase complex, thereby preventing the activation of CARD 8 within inflammasomes. Similarly, Bay 11-7082 irreversibly inhibits the phosphorylation of IκBα, which is necessary for the activation of NF-kB and subsequently reduces CARD 8 activity. Sulforaphane also targets this pathway by preventing the degradation of IκBα, maintaining the repression of NF-kB and thus CARD 8's inflammasome activity. Disulfiram contributes to this cascade by reducing NF-kB pathway activity, which in turn would diminish CARD 8's functional role in inflammasome formation. MG132, as a proteasome inhibitor, stabilizes IκBα and decreases the activity of NF-kB, leading to a functional inhibition of CARD 8.
Continuing with the theme of NF-kB pathway inhibition, QNZ, also known as EVP4593, prevents the nuclear translocation of the NF-kB subunit p65, thereby curtailing CARD 8 activation. PDTC follows suit by obstructing NF-kB signaling, which is essential for the activation of CARD 8 in inflammasomes. Andrographolide, through its inhibitory effect on NF-kB activation, impedes the functionality of CARD 8 in inflammasome assembly. Triptolide's inhibition of the NF-kB pathway reduces the expression of pro-inflammatory cytokines and the activation of downstream proteins like CARD 8. Capsazepine blocks NF-kB pathway activation, crucial for CARD 8 function within the inflammasome complex. Isoliquiritigenin prevents the phosphorylation and degradation of IκBα, leading to CARD 8 inhibition. Lastly, curcumin is known for its capacity to inhibit the NF-kB pathway, consequently downregulating the activation of CARD 8 involved in inflammatory responses.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide inhibits the NF-kB pathway by blocking the IκB kinase complex, which is upstream of CARD 8 in the inflammatory signaling cascade. Inhibition of NF-kB prevents the activation of CARD 8-involved inflammasome assembly. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 irreversibly inhibits the phosphorylation of IκBα, which impedes NF-kB activation, an upstream regulator of CARD 8. This results in the functional inhibition of CARD 8 by preventing its inflammasome activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is known to inhibit the NF-kB pathway by preventing the degradation of IκBα, thereby inhibiting the activation of NF-kB and subsequent downregulation of CARD 8 activation within inflammasomes. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can inhibit the NF-kB pathway, thereby reducing the activity of downstream elements like CARD 8 by preventing the transcription of NF-kB target genes that could be involved in CARD 8 activation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 acts as a proteasome inhibitor that can prevent the degradation of IκBα, an inhibitor of NF-kB. Stabilization of IκBα results in reduced activity of NF-kB and thus decreased CARD 8 inflammasome formation. | ||||||
QNZ | 545380-34-5 | sc-200675 | 1 mg | $117.00 | 12 | |
QNZ inhibits NF-kB activation by blocking the nuclear translocation of p65, a subunit of NF-kB. This leads to reduced activity of downstream proteins like CARD 8 that are involved in inflammasome assembly. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
PDTC inhibits the NF-kB pathway, which is upstream of CARD 8, thus preventing the activation of CARD 8 and its involvement in the inflammasome complex. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide has been shown to inhibit NF-kB activation, which is necessary for the functional activity of CARD 8 in inflammasome assembly, thus functionally inhibiting CARD 8. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits the NF-kB pathway, which reduces the expression of pro-inflammatory cytokines and the activation of proteins like CARD 8 that are part of the inflammasome. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $148.00 $459.00 | 11 | |
Capsazepine blocks the activation of the NF-kB pathway, which is required for the activation of CARD 8 in the inflammasome complex, thereby inhibiting CARD 8 function. | ||||||