CaMKIγ Activators
CaMKIγ, being integral to calcium signaling cascades, relies on the precise regulation of intracellular calcium dynamics. Chemicals influencing calcium concentration indirectly govern CaMKIγ's activation status. Compounds like Forskolin, which amplify cAMP levels, delineate the crosstalk between cyclic nucleotide signaling and calcium dynamics, hinting at the indirect ways in which CaMKIγ can be modulated. The narrative of calcium signaling is further nuanced by agents like NMDA, which facilitate calcium entry via receptor channels, and L-type calcium channel agonists, underscoring the receptor and channel-mediated regulatory mechanisms.
Furthermore, chemicals such as PMA and OAG shed light on protein kinase C (PKC) related modulation, emphasizing the interplay between different kinase pathways and calcium signaling. The broader calcium landscape also entertains compounds like BAPTA-AM, Caffeine, and Thapsigargin, each uniquely influencing calcium stores and their release dynamics. Collectively, these compounds elucidate the intricate web of calcium-centric regulatory processes that can converge on CaMKIγ, reinforcing its cardinal role in translating calcium signals to cellular actions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Introduces calcium into cells, thereby increasing intracellular calcium, which activates calmodulin and can subsequently activate CaMKIγ. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator, increasing cAMP levels. cAMP can modulate calcium signaling, indirectly influencing CaMKIγ. | ||||||
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $107.00 $362.00 | 2 | |
Glutamate receptor activator; calcium influx through NMDA receptors can activate calmodulin, indirectly leading to CaMKIγ activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PKC activators that influence various calcium channels and signaling cascades, which can indirectly modulate CaMKIγ. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
Intracellular calcium chelator. While it primarily decreases calcium, its dynamics in cells can indirectly influence CaMKIγ. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Promote calcium influx, indirectly activating calmodulin and potentially CaMKIγ. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Releases intracellular calcium by acting on ER stores, which can lead to calmodulin activation and subsequent CaMKIγ modulation. | ||||||
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $117.00 $444.00 | 1 | |
Analog of diacylglycerol (DAG) and can activate PKC, potentially affecting pathways that influence CaMKIγ. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Inhibits the sarco-/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased intracellular calcium, which can activate CaMKIγ. | ||||||