CaMKIγ Antibody (10G8): sc-134296
- CaMKIγ Antibody (10G8) is a mouse monoclonal IgG2a κ CaMKIγ antibody provided at 100 µg/ml
- raised against recombinant CaMKIγ protein of human origin
- recommended for detection of CaMKIγ of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CaMKIγ Antibody (10G8). This work is in progress.
CaMKIγ Antibody (10G8) is a mouse monoclonal IgG2a kappa light chain antibody that detects CaMKIγ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CaMKIγ antibody (10G8) is available as a non-conjugated isotype antibody. The Ca2+/calmodulin-dependent protein kinases (CaMKs) are a crucial subfamily of serine/threonine kinases, and CaMKIγ, also known as VWS1 or CLICKIII, plays a significant role in cellular signaling pathways. This 476 amino acid protein localizes primarily in the cytoplasm and Golgi apparatus membrane, essential for regulating various cellular processes. The Golgi apparatus is vital for protein sorting and modification, and CaMKIγ presence in this organelle suggests involvement in post-translational modifications of proteins, including phosphorylation. CaMKIγ shows predominant expression in the brain, with lower levels in the spleen, liver, kidney, and skeletal muscle, functioning as a calcium/calmodulin-dependent protein kinase that utilizes ATP to phosphorylate target proteins, such as transcription factor CREB-1. Multiple alternatively spliced isoforms of CaMKIγ, encoded by a gene on human chromosome 1, further highlight its complexity and potential regulatory roles in various physiological processes.
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CaMKIγ Antibody (10G8) References:
- The Ca-calmodulin-dependent protein kinase cascade. | Soderling, TR. 1999. Trends Biochem Sci. 24: 232-6. PMID: 10366852
- A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. | Schutte, BC., et al. 2000. Genome Res. 10: 81-94. PMID: 10645953
- Ca(2+)/CaM-dependent kinases: from activation to function. | Hook, SS. and Means, AR. 2001. Annu Rev Pharmacol Toxicol. 41: 471-505. PMID: 11264466
- Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). | Takemoto-Kimura, S., et al. 2003. J Biol Chem. 278: 18597-605. PMID: 12637513
- Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase I gamma in the rat brain. | Nishimura, H., et al. 2003. J Neurochem. 85: 1216-27. PMID: 12753081
- Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma. | Takemoto-Kimura, S., et al. 2007. Neuron. 54: 755-70. PMID: 17553424
- Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease. | Colomer, J. and Means, AR. 2007. Subcell Biochem. 45: 169-214. PMID: 18193638
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CaMKIγ Antibody (10G8) | sc-134296 | 100 µg/ml | $333.00 |