N-Methyl-D-Aspartic acid (NMDA) is a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. The NMDA receptor is a voltage-gated ion channel closely involved in memory, in spatial learning and perturbing the normal behavior of this receptor system with NMDA exposure has facilitated elucidation of NMDA receptor-mediated activities.
1. Watkins, J.C., et al. 1981. Annu. Rev. Pharmacol. Toxicol. 21: 165-204. PMID: 6112965 2. Hansen, J.J., et al. 1990. Med Res Rev. 10: 55-94. PMID: 2153264 3. Cain, D.P. 1998. Neurosci Biobehav Rev. 22: 181-193. PMID: 9579310 4. Manfridi, A., et al. 1999. Am. J. Physiol. 277: R1488-R1492. PMID: 10564223
Soluble in water (100 mM ), dilute aqueous base, and ethanol.
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Various publications cite NVarious publications cite N-Methyl-D-Aspartic acid (NMDA) as a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. -SCBT Publication Review
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