CALR3 Activators
CALR3 Activators represent a class of chemical compounds that indirectly modulate the activity of the CALR3 (Calreticulin 3) protein. CALR3 is a calcium-binding protein with diverse cellular functions. While direct activators of CALR3 may not be extensively characterized, these activators impact CALR3 function through their influence on calcium homeostasis and associated cellular processes. One approach to activating CALR3 indirectly involves the use of calcium modulators such as Thapsigargin, BAPTA-AM, and A23187. Thapsigargin inhibits the SERCA pump, leading to calcium release from the endoplasmic reticulum (ER) and disruption of calcium homeostasis. BAPTA-AM is a cell-permeable calcium chelator that reduces intracellular calcium levels, impacting CALR3's calcium-binding functions. A23187 facilitates calcium transport across cellular membranes, potentially altering calcium concentrations within cells and affecting CALR3-related calcium-dependent processes.
Another group of CALR3 activators includes compounds like Thioridazine, Verapamil, and Dantrolene. Thioridazine is a dopamine receptor antagonist that may indirectly influence CALR3 by modulating cellular signaling pathways associated with CALR3 function. Verapamil is a calcium channel blocker that can indirectly affect CALR3 by regulating calcium influx into cells through calcium channels, which impacts calcium-dependent processes involving CALR3. Dantrolene, a skeletal muscle relaxant, inhibits calcium release from the sarcoplasmic reticulum, potentially influencing CALR3 in cells with skeletal muscle involvement.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator. Its use can indirectly influence CALR3 by modulating intracellular calcium levels, which are crucial for CALR3's calcium-binding functions. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that facilitates the transport of calcium ions across cellular membranes. Its use can indirectly impact CALR3 by altering calcium concentrations within cellular compartments. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
Thioridazine is a dopamine receptor antagonist. Its potential indirect influence on CALR3 could be via effects on cellular signaling pathways associated with CALR3 function. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene is a skeletal muscle relaxant that acts by inhibiting calcium release from the sarcoplasmic reticulum. This mechanism may indirectly affect CALR3 in cells with skeletal muscle involvement. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red is a non-specific calcium ionophore blocker. Its use can indirectly affect CALR3 by modulating calcium ion influx or efflux, impacting calcium-dependent processes involving CALR3. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is a calcium channel modulator. Its use can indirectly impact CALR3 by altering calcium channel activity, influencing calcium signaling pathways that intersect with CALR3 functions. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
EGTA is a calcium chelator used to sequester extracellular calcium ions. Its application can indirectly affect CALR3 by controlling calcium levels in the extracellular environment, which may impact CALR3 interactions. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is an inhibitor of the vacuolar-type H+-ATPase. Its use can indirectly influence CALR3 by impacting the acidic cellular environment, which may be relevant to CALR3 functions within cellular compartments. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionophore ionomycin facilitates calcium ion transport across membranes. Its application can indirectly affect CALR3 by altering calcium concentrations within cellular compartments and calcium-dependent processes. | ||||||