Calpain 3 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionophore that specifically binds and transports calcium ions across membranes, raising intracellular calcium levels. This elevation in calcium directly activates Calpain 3 by providing the necessary ions for its enzymatic function. | ||||||
BAY K 8644, S(−)- | 98625-26-4 | sc-203525 sc-203525A | 10 mg 50 mg | $398.00 $1428.00 | 1 | |
A dihydropyridine that acts as an L-type calcium channel agonist, promoting the influx of calcium into the cell. Increased intracellular calcium levels subsequently activate Calpain 3 by satisfying its calcium requirement for activation. | ||||||
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $38.00 $1155.00 $122.00 | 3 | |
Blocks voltage-gated potassium channels, which prolongs action potentials and enhances calcium entry into neurons through voltage-dependent calcium channels, thereby increasing the intracellular calcium concentration and indirectly activating Calpain 3. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A sesquiterpene lactone that inhibits the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to an increase in cytosolic calcium concentration and thereby indirectly activates Calpain 3. | ||||||
Pimozide | 2062-78-4 | sc-203662 | 100 mg | $104.00 | 3 | |
Blocks dopamine receptors, which leads to alterations in intracellular signaling pathways, including those regulating calcium homeostasis. This can result in increased calcium levels, thereby activating Calpain 3. | ||||||
FPL-64176 | 120934-96-5 | sc-201491 | 5 mg | $83.00 | 1 | |
Selective L-type calcium channel activator which increases calcium influx into the cell, thus indirectly activating Calpain 3 by providing higher intracellular calcium necessary for its activity. | ||||||
Aristolochic Acid | 313-67-7 | sc-200731 | 25 mg | $96.00 | 2 | |
Inhibits nitric oxide synthase, which can lead to an increase in intracellular calcium concentrations and thereby indirectly activate Calpain 3. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Inhibits the SERCA, causing an increase in cytosolic calcium levels that in turn activates Calpain 3. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that increases intracellular calcium concentration by transporting calcium across the cell membrane, which directly activates Calpain 3. | ||||||