Aristolochic Acid (CAS 313-67-7)
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Aristolochic Acid is employed in research focused on understanding its interaction with DNA and the subsequent effects on cellular mechanisms. Studies often investigate how Aristolochic Acid binds to DNA, leading to mutations that researchers can observe and analyze, particularly in the context of genetic studies. Additionally, Aristolochic Acid is used in biochemical research to examine its impact on the activation of various signaling pathways including those related to cellular stress responses. In environmental toxicology, Aristolochic Acid serves as a subject for studying toxin exposure and its effects on wildlife and ecosystems. Moreover, its role in inducing certain cellular responses makes Aristolochic Acid a valuable compound for studies aimed at understanding the molecular basis of cell cycle regulation and apoptosis.
Aristolochic Acid (CAS 313-67-7) References
- Mycotoxic and aristolochic acid theories of the development of endemic nephropathy. | Peraica, M., et al. 2008. Arh Hig Rada Toksikol. 59: 59-65. PMID: 18407872
- Aristolochic acid suppresses DNA repair and triggers oxidative DNA damage in human kidney proximal tubular cells. | Chen, YY., et al. 2010. Oncol Rep. 24: 141-53. PMID: 20514455
- Aristolochic acid I metabolism in the isolated perfused rat kidney. | Priestap, HA., et al. 2012. Chem Res Toxicol. 25: 130-9. PMID: 22118289
- Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils. | Rosenthal, MD., et al. 1989. Biochim Biophys Acta. 1001: 1-8. PMID: 2536283
- Aristolochic acid induced suicidal erythrocyte death. | Malik, A., et al. 2014. Kidney Blood Press Res. 39: 408-19. PMID: 25412628
- Aristolochic acid I is a substrate of BCRP but not P-glycoprotein or MRP2. | Ma, L., et al. 2015. J Ethnopharmacol. 172: 430-5. PMID: 26183576
- Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid. | Vishwanath, BS., et al. 1988. Inflammation. 12: 549-61. PMID: 3220517
- Aristolochic acid induces mitochondrial apoptosis through oxidative stress in rats, leading to liver damage. | Wang, Y., et al. 2021. Toxicol Mech Methods. 31: 609-618. PMID: 34167444
- The recognition of aristolochic acid I based on fluorescence quenching of bovine serum albumin-stabilized gold nanoclusters. | Lu, Y., et al. 2022. Anal Methods. 14: 1963-1972. PMID: 35531633
- Aristolochic acid I induces proximal tubule injury through ROS/HMGB1/mt DNA mediated activation of TLRs. | Upadhyay, R. and Batuman, V. 2022. J Cell Mol Med. 26: 4277-4291. PMID: 35765703
- Curcumin alleviates aristolochic acid nephropathy based on SIRT1/Nrf2/HO-1 signaling pathway. | Liu, Z., et al. 2022. Toxicology. 479: 153297. PMID: 36037877
- Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid. | Vishwanath, BS., et al. 1987. Toxicon. 25: 501-15. PMID: 3617087
- Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells. | Komatsu, M., et al. 2023. Toxicol Lett. 378: 39-50. PMID: 36863539
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aristolochic Acid, 25 mg | sc-200731 | 25 mg | $96.00 |