BAY K 8644, S(−)- (CAS 98625-26-4)

BAY K 8644, specifically the S(−)-enantiomer, is a potent chemical modulator of calcium channels, primarily targeting the L-type calcium channels which are for the regulation of calcium influx in various cell types. This compound acts as an agonist, enhancing the channel′s opening probability, which leads to an increased intracellular calcium concentration. The mechanism by which BAY K 8644 exerts its effect involves binding to the channel in a state-dependent manner, preferentially associating with and stabilizing the open state of the channel. This unique action makes it an invaluable tool in research, especially in studies aimed at understanding the physiological and pathological roles of L-type calcium channels in cellular processes. Through its ability to modulate calcium dynamics precisely, BAY K 8644 has facilitated the exploration of calcium′s pivotal role in signaling pathways, cellular contraction, and secretion processes, thereby contributing significantly to the advancement of cellular and molecular biology research fields. When used in conjunction with BIX01294, BAY K 8644, S(−)- facilitates the reprogramming of mouse embryonic fibroblasts following transduction with Oct4/Klf4.5. BAY K 8644, S(−)- is specifically methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate, with an (S)-configuration at the 4-position.