CALHM3 Activators
CALHM3 activators are a class of chemical compounds that selectively target and enhance the function of the CALHM3 protein, a member of the calcium homeostasis modulator (CALHM) family. As an ion channel protein, CALHM3 is integral to the regulation of calcium ion flux across cellular membranes-a process that is vital to numerous cellular signaling pathways. The ability of CALHM3 to facilitate the movement of calcium ions into and out of cells and intracellular compartments is essential for maintaining the delicate balance of calcium concentrations that cells require to function properly. CALHM3 activators work by increasing the ion channel's conductivity or by affecting the channel's gating mechanisms, thus promoting greater calcium ion permeability.
The specific action of CALHM3 activators can lead to an upsurge in intracellular calcium levels, which in turn can influence a variety of calcium-dependent cellular processes. These include neurotransmitter release in neurons, muscle contraction, and various metabolic pathways. The exact mechanism by which CALHM3 activators enhance the channel's function may differ among various compounds, depending on their affinity for the channel, their binding site, and how they influence the channel's structure to favor the open state. The study of these activators provides valuable insight into the functional dynamics of CALHM3 channels and the complex role of calcium signaling in cellular physiology. By elucidating the molecular interactions that govern the activity of CALHM3, researchers are able to better understand how cells regulate calcium levels and how perturbations in this balance can affect overall cellular health.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, known to stimulate gene expression, might hypothetically induce CALHM3 by promoting the binding of transcription factors to the CALHM3 gene promoter region. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin could potentially increase CALHM3 expression by activating intracellular signaling pathways that enhance the transcription of CALHM3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, through its gene modulation properties, might hypothetically stimulate the transcription machinery leading to increased CALHM3 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate might hypothetically stimulate CALHM3 expression by activating pathways that promote protein transcription and thus enhance CALHM3 gene transcription. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane, known to induce several proteins, could hypothetically increase CALHM3 expression by modulating transcription factor activity favoring CALHM3 transcription. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin might hypothetically stimulate CALHM3 expression by enhancing the activity of transcription factors that bind to the promoter region of the CALHM3 gene. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein might hypothetically induce CALHM3 expression by modulating intracellular signaling pathways that lead to increased transcription of the CALHM3 gene. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin could potentially increase CALHM3 expression by modulating cellular pathways that lead to enhanced gene transcription, potentially affecting CALHM3. | ||||||
Daidzein | 486-66-8 | sc-24001 sc-24001A sc-24001B | 100 mg 500 mg 5 g | $28.00 $79.00 $165.00 | 32 | |
Daidzein could hypothetically stimulate the transcription machinery that increases CALHM3 production by influencing the activity of related transcription factors. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Lycopene might hypothetically induce CALHM3 expression by influencing signal transduction pathways that lead to increased gene transcription, potentially including CALHM3. | ||||||