CALCOCO1 Inhibitors
Chemical inhibitors of CALCOCO1 function by disrupting various stages of the autophagic process, which CALCOCO1 is known to be involved in. Bafilomycin A1 and Concanamycin A target the V-ATPase complex, essential for acidifying intracellular vesicles. By inhibiting this acidification, these chemicals prevent the maturation of autophagosomes and their subsequent fusion with lysosomes, a process in which CALCOCO1 is implicated. Similarly, Chloroquine and its more potent derivative Lys05 raise the pH in lysosomes, impairing the degradation process within autolysosomes and thereby inhibiting CALCOCO1's function related to autophagic turnover. Monensin also disrupts lysosomal acidification, further preventing the fusion between autophagosomes and lysosomes, which is a critical step where CALCOCO1 exerts its function.
On the other hand, chemicals such as 3-Methyladenine, Wortmannin, LY294002, and Spautin-1 inhibit different classes of phosphatidylinositol 3-kinases (PI3Ks) or promote the degradation of their complexes, essential for the nucleation and formation of autophagosomes. By preventing the initial steps of autophagosome formation, these inhibitors obstruct the pathway at an early stage, thus functionally inhibiting CALCOCO1 by not allowing it to participate in later stages of autophagy. Furthermore, Vinblastine and Paclitaxel disrupt microtubule dynamics which are crucial for autophagosome trafficking and eventual fusion with lysosomes, a cellular trafficking route that is essential for CALCOCO1 function. SAR405 specifically inhibits the Vps34 PI3K complex, which has a pivotal role in autophagy initiation. The inhibition of Vps34 directly impacts the formation of autophagosomes, thus inhibiting CALCOCO1's function in the autophagic pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 inhibits V-ATPase, which acidifies intracellular vesicles. CALCOCO1 is involved in autophagy and the inhibition of vesicle acidification can hinder autophagosome-lysosome fusion, thereby functionally inhibiting CALCOCO1. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine raises the pH in lysosomes, which could impair the degradation process within autolysosomes, indirectly inhibiting CALCOCO1's function in autophagic turnover. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine inhibits class III PI3K, which is involved in the initial steps of autophagosome formation. By preventing autophagosome formation, CALCOCO1's role in autophagy is functionally inhibited. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. By inhibiting PI3K, it can prevent the formation of autophagosomes, indirectly inhibiting CALCOCO1's function in the autophagic pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits class I PI3Ks, leading to a reduction in autophagosome formation. This action can functionally inhibit CALCOCO1 by preventing its role in autophagy. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 promotes the degradation of class III PI3K complexes, leading to reduced autophagosome formation and indirectly inhibiting CALCOCO1's autophagic function. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule dynamics, which can inhibit autophagosome trafficking and fusion with lysosomes, thus functionally inhibiting CALCOCO1's role in autophagy. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can disrupt autophagosome dynamics. This action may functionally inhibit CALCOCO1 by impairing autophagosome-lysosome fusion. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin disrupts lysosomal acidification and autophagosome-lysosome fusion, functionally inhibiting CALCOCO1's role in autophagy by preventing the final steps of the autophagic process. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A, like Bafilomycin A1, is a V-ATPase inhibitor that prevents acidification of intracellular vesicles, functionally inhibiting CALCOCO1 by impairing autophagosome-lysosome fusion. | ||||||