C5orf54 Activators
C5orf54 activators encompass a variety of chemical entities that engage specific cellular pathways, ultimately leading to the protein's enhanced functional activity. For instance, certain small molecules can interact with adenylate cyclase, thereby increasing intracellular levels of cyclic AMP, a secondary messenger that is pivotal in activating protein kinase A. The subsequent activation of this kinase may result in the phosphorylation of proteins within the signaling network of C5orf54, thereby increasing its activity. Furthermore, agents that elevate intracellular calcium concentrations can act as indirect activators. Calcium ionophores facilitate an influx of calcium ions, triggering cascades that activate calcium-dependent protein kinases. These kinases, once activated, are capable of phosphorylating substrates that are part of the regulatory framework of C5orf54, which, in turn, could lead to an enhancement of its activity.
Moreover, compounds that target G-protein coupled receptors, such as beta-adrenergic agonists, initiate a cascade that also elevates cyclic AMP, further potentiating the kinase pathways involved in the regulation of C5orf54. Stress-activated protein kinase pathways, including those regulated by anisomycin, contribute to theactivation of C5orf54 by modulating transcriptional regulators through phosphorylation. Additionally, phosphodiesterase inhibitors indirectly elevate cAMP and cGMP levels, which can activate protein kinases like PKA and PKG, thus influencing the regulatory proteins associated with C5orf54. Other molecules activate protein kinase C, which has a wide array of cellular targets, potentially including those that mediate C5orf54 activation. Finally, compounds such as capsaicin, which bind to and activate TRPV1 channels, result in increased intracellular calcium that may, in turn, activate kinases with the ability to phosphorylate and enhance the activity of C5orf54.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases can phosphorylate C5orf54, thereby increasing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
This compound activates protein kinase C (PKC), which can phosphorylate substrates involved in the regulation of C5orf54, leading to its activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin triggers the PI3K/AKT pathway, which is involved in cell survival and growth. Activation of this pathway can lead to the phosphorylation and activation of downstream targets, potentially including C5orf54. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine activates G-protein coupled receptors that stimulate adenylate cyclase, increasing cAMP levels and activating PKA. PKA can then phosphorylate and activate C5orf54 as part of the signaling cascade. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium, activating calcium-dependent kinases that could phosphorylate and enhance the activity of C5orf54. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor which activates stress-activated protein kinases like JNK. JNK activation can lead to the phosphorylation of certain transcription factors that increase the activity of C5orf54. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that raises cAMP levels, leading to PKA activation. PKA can phosphorylate proteins involved in the signaling pathway of C5orf54, thereby enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases which leads to increased cAMP and cGMP levels in cells. Elevated levels of these cyclic nucleotides can activate PKA and PKG, potentially leading to the activation of C5orf54. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates TRPV1, a calcium-permeable channel, leading to an influx of calcium ions. The increase in intracellular calcium may activate kinases that can phosphorylate and increase the activity of C5orf54. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analogue that can permeate cell membranes and activate PKA intracellularly. PKA activation may result in the phosphorylation of C5orf54 or proteins that regulate C5orf54, enhancing its activity. | ||||||