C1D Inhibitors
Chemical inhibitors of C1D can interfere with the protein's function through various mechanisms related to the DNA repair process in which the protein is involved. Staurosporine, a potent kinase inhibitor, can inhibit the kinases that are crucial for signaling pathways linked to DNA damage response, thus impeding C1D's activation. Similarly, UCN-01, which selectively targets protein kinase C, directly impacts the cell cycle control and DNA damage response, resulting in the inhibition of C1D. This disruption in kinase activity has a direct effect on C1D's role within the cell's DNA repair mechanisms.
Furthermore, chemicals that target DNA replication and repair enzymes can also indirectly affect the function of C1D. For instance, camptothecin and etoposide inhibit topoisomerase I and II, respectively, enzymes that are essential for DNA replication and repair. The functional inhibition of these enzymes can lead to a cascade of effects that hinders C1D's activities in DNA repair. Aphidicolin's specific inhibition of DNA polymerases alpha and delta leads to the impairment of DNA synthesis and repair mechanisms, affecting the role of C1D. Mitomycin C creates crosslinks within DNA, leading to damage that can disrupt C1D-involved processes. Actinomycin D, by intercalating into DNA, can stall the transcription process required for DNA repair mechanisms, therefore indirectly inhibiting C1D. Moreover, caffeine is known to interfere with several DNA repair pathways, which would hinder C1D's proper function. NU7441, as a potent DNA-PK inhibitor, would affect the non-homologous end joining pathway, an area where C1D is active in DNA repair, hence, indirectly inhibiting C1D. In a similar fashion, the inhibition of PARP by olaparib disrupts the single-strand break repair process, wherein C1D may be involved. Lastly, the inhibitors LY294002 and KU-55933, which target PI3K and ATM kinase respectively, would interfere with the signaling pathways of cell survival and DNA damage response, affecting C1D's role in these processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. C1D has been implicated in DNA repair processes and kinase activity is crucial for signaling related to DNA damage response, thus staurosporine can inhibit C1D by inhibiting kinases involved in its activation. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor. Since C1D is involved in DNA repair and topoisomerase I is essential for DNA replication and transcription, the inhibition of topoisomerase I by camptothecin could result in the functional inhibition of C1D by hindering the DNA processes it is associated with. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide targets topoisomerase II, which is another enzyme important in DNA replication and repair. Inhibition of topoisomerase II can indirectly inhibit C1D by blocking the DNA repair mechanism in which C1D is involved. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a specific inhibitor of DNA polymerase alpha and delta. C1D, associated with DNA repair, would be functionally inhibited due to the impairment of DNA synthesis and repair mechanisms due to aphidicolin's inhibitory action on these polymerases. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and prevents RNA synthesis by inhibiting RNA polymerases. This action can indirectly inhibit C1D by stalling the transcription process required for DNA repair mechanisms. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C forms crosslinks within DNA strands. C1D, being a protein involved in DNA repair pathways, would be functionally inhibited as mitomycin C causes DNA damage that can disrupt the processes C1D is involved in. | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $246.00 | 10 | |
UCN-01 is a selective inhibitor of protein kinase C. As C1D function is connected to DNA repair, and protein kinase C is involved in cell cycle control and DNA damage response, inhibition of this kinase by UCN-01 can result in functional inhibition of C1D. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine has been shown to inhibit several DNA repair pathways. Given C1D's role in DNA repair, the inhibition of these pathways by caffeine would hinder the proper function of C1D. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
NU7441 is a potent DNA-dependent protein kinase inhibitor. Since C1D is implicated in the non-homologous end joining (NHEJ) pathway of DNA repair, inhibition of DNA-PK by NU7441 can indirectly inhibit the functional activity of C1D in DNA repair. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib is a PARP inhibitor. PARP enzymes play a role in single-strand break repair, and C1D is involved in DNA repair pathways. By inhibiting PARP, olaparib could indirectly inhibit C1D by disrupting the single-strand break repair process in which C1D may participate. | ||||||