C1D Activators
C1D Activators are a diverse array of compounds that indirectly enhance the functional activity of C1D through various signaling pathways, each with a unique mechanism of action. The adenylate cyclase activator Forskolin, and the cAMP analog 8-Bromo-cAMP, both lead to elevated cAMP levels that activate PKA. This activation can lead to the phosphorylation of proteins involved in the DNA repair and transcriptional regulation processes that C1D is a part of. Similarly, the ionophore Ionomycin raises intracellular calcium levels, which can enhance C1D's role in calcium-dependent signaling pathways, crucial during cellular stress responses. The PKC activator, Phorbol 12-myristate 13-acetate (PMA), may induce phosphorylation events that modulate C1D's involvement in apoptotic signaling, while Spermidine indirectly supports C1D's function by facilitating autophagic processes that might remove inhibitory proteins.
Further enhancing C1D's activity are compounds that influence various regulatory pathways: Curcumin modulates the NF-κB pathway, potentially affecting C1D's role in inflammatory responses; Resveratrol activates sirtuin pathways, which may augment C1D's chromatin remodeling and transcription regulation roles. Polyphenols like Epigallocatechin gallate (EGCG) inhibit kinases, reducing competition for C1D's binding sites and thus potentially increasing its involvement in DNA repair.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can lead to the activation of PKA. PKA phosphorylates numerous targets that could enhance the DNA repair and transcriptional functions of C1D. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially enhancing C1D's role in calcium-dependent signaling pathways related to cell stress responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate substrates that modulate C1D's involvement in signal transduction related to apoptosis. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
As a cAMP analog, 8-Bromo-cAMP can mimic cAMP's role in activating PKA, thereby potentially enhancing C1D's interaction with other proteins in transcription complexes. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is known to indirectly facilitate autophagy, which might lead to the selective degradation of inhibitors of C1D, thus increasing its functional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate NF-κB pathway activity, which might affect C1D's role in inflammatory response and DNA damage response pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin pathways, which could enhance C1D's function in chromatin remodeling and regulation of transcription under stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein kinases, potentially reducing competition for C1D binding sites on shared targets in DNA repair complexes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can modulate AKT signaling, potentially influencing C1D-mediated pathways in apoptosis and cell survival. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is another MEK inhibitor that could similarly shift signaling to enhance C1D function in response to DNA damage. | ||||||